Nucleus Pulposus Allograft Retards Intervertebral Disc Degeneration
| Autor: | Kazuhiro Nishimura, Joji Mochida, Kou Sakabe, Takeshi Nomura, Masahiko Okuma |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
musculoskeletal diseases
Pathology medicine.medical_specialty Time Factors Cell Type II collagen Degeneration (medical) Extracellular matrix Animals Medicine Orthopedics and Sports Medicine Intervertebral Disc Lagomorpha biology business.industry Neurodegenerative Diseases Intervertebral disc General Medicine musculoskeletal system biology.organism_classification Intervertebral disk medicine.anatomical_structure Spinal Diseases Surgery Rabbits business Nucleus |
| Zdroj: | Clinical Orthopaedics and Related Research. 389:94-101 |
| ISSN: | 0009-921X |
| DOI: | 10.1097/00003086-200108000-00015 |
| Popis: | Autogenous implantation of nucleus pulposus or nucleus pulposus cells that were activated by coculture retards intervertebral disc degeneration, but harvesting such grafts causes disc degeneration at the donor site. This study examined whether nucleus pulposus allografts similarly retard disc degeneration and whether such allografting induces immunologic rejection. Japanese White rabbits served as donors and recipients for allografts. Lumbar disc degeneration was induced by aspirating the nucleus pulposus. Two weeks later, intact nucleus pulposus or nucleus pulposus cells were injected and compared with a sham procedure and normal control. The recipients' discs were examined histologically and immunologically at intervals for 16 weeks. Discs receiving an intact nucleus pulposus showed the least degeneration, followed by discs receiving nucleus pulposus cells, both of which were better than no treatment. These findings correlated directly with the intensity of immunochemical staining for Type II collagen. Allogeneic grafts did not induce any appreciable host-versus-graft response. Injection of nucleus pulposus and nucleus pulposus cells retards intervertebral disc degeneration. However, injection of intact nucleus pulposus is more effective than injection of nucleus pulposus cells alone. The intercellular matrix plays an important, but poorly understood, role in preserving intervertebral discs. |
| Databáze: | OpenAIRE |
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