The Effects of Therapeutic Intermittent Hypoxia Implementation on Complete Blood Count Parameters: An Experimental Animal Model

Autor: Talha KILIÇ, Mustafa SENGOR, Savaş ÜSTÜNOVA, Aysu KILIC, Hayrettin DAŞKAYA, Aysel Yıldız ÖZER
Přispěvatelé: Kılıç T., Şengör M., Üstünova S., Kılıç A., Daşkaya H., Yıldız Özer A., ÜSTÜNOVA, SAVAŞ, DAŞKAYA, HAYRETTİN, KILIÇ, AYSU
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Volume: 12, Issue: 3 746-752
Clinical and Experimental Health Sciences
ISSN: 2459-1459
Popis: Objective: Intermittent hypoxia (IH) implementation is a method performed by intermittently decreasing oxygen concentration in inhaled air at specific rate. This method varies between studies in terms of its application. This study aims to examine the changes in Complete Blood Count (CBC) parameters caused by IH implementation at therapeutic dose ranges with a single model. Methods: Ten Sprague Dawley type adult male rats were divided into two groups. In the study group, FiO2 level of inhaled air, was reduced to 10% in hypoxic cycle. 5 minutes normoxia-hypoxia cycle was used in each 30 minutes experiment period for study group. Control group remained in normoxic air for 30 minutes. 1 cc of blood was taken from mandibular vein from all rats at the end of 6th day. CBC analyzes were performed and differences between two groups were investigated. Results: Significant differences were detected in some CBC parameters between the two groups. It was determined that significant increase in MONO (p
Databáze: OpenAIRE
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