Effect of cholecystectomy on bile acid diarrhoea biomarkers: A prospective clinical study
| Autor: | Signe Wildt, Jüri J. Rumessen, Christian Borup, Nora Hedbäck, Pierre Bouchelouche, Emilie Gauliard, Dominique Rainteau, Lars Kristian Munck |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Borup, C, Hedbäck, N, Wildt, S, Rumessen, J J, Bouchelouche, P, Gauliard, E, Rainteau, D & Munck, L K 2021, ' Effect of cholecystectomy on bile acid diarrhoea biomarkers: A prospective clinical study ', GastroHep, vol. 3, no. 5, pp. 283-290 . https://doi.org/10.1002/ygh2.489 |
| ISSN: | 1478-1239 |
| DOI: | 10.1002/ygh2.489 |
| Popis: | BackgroundThe pathophysiological mechanisms of bile acid diarrhoea after cholecystectomy are unknown. Therefore, we aimed to explore the effects of cholecystectomy on the plasma biomarkers of bile acid diarrhoea: fibroblast growth factor 19 and 7α-hydroxy-4-cholesten-3-one.MethodsPatients were examined prospectively before and after cholecystectomy. Diary registration of bowel habits with the Bristol stool scale was done for 7 days before each visit. Blood was collected at fasting and after ingestion of a solid study meal with 1250 mg unconjugated chenodeoxycholic acid. Plasma fibroblast growth factor 19 was measured with enzyme-linked immunosorbent assay and the complete bile acid profile including 7α-hydroxy-4-cholesten-3-one with high-performance liquid chromatography–tandem mass spectrometry.ResultsEighteen patients completed the study. The median postoperative follow-up time was 4.6 months (interquartile range [IQR] 3.9-5.8). Diary-registered bowel movement frequency and stool consistency were unchanged; none developed diarrhoea. Before cholecystectomy, mean fibroblast growth factor 19 was 102 pg/mL (95% CI 74-141) vs 92 pg/mL (67-125) after (P = .29; paired t test). Following the meal, the median 150-minute increment from fasting in fibroblast growth factor 19 was 81 pg/mL (IQR: −20 to 274) before and 186 pg/mL (111-382) after cholecystectomy (P = .03; Wilcoxon-test). Mean fasting 7α-hydroxy-4-cholesten-3-one was unchanged 6.0 ng/mL (4.1-8.7) vs 7.5 ng/mL (5.5-10.0) (P = .63; paired t test).ConclusionsThe stimulated postprandial response in fibroblast growth factor 19 increased after cholecystectomy, whereas fasting plasma biomarkers and bowel habits did not change significantly 3-6 months after cholecystectomy. ClinicalTrials.gov: NCT03168555. |
| Databáze: | OpenAIRE |
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