Effect of acetaldehyde on urinary salsolinol in healthy man after ethanol intake
| Autor: | M. Kogame, Yasuhiko Mizoi, Junko Adachi, Ichiya Ninomiya, Tatsushige Fukunaga, Takeaki Naito |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male medicine.medical_specialty Health (social science) Urinary system Aldehyde dehydrogenase Acetaldehyde Urine Toxicology Biochemistry Excretion Behavioral Neuroscience chemistry.chemical_compound Catecholamines Internal medicine medicine Humans Volunteer Ethanol biology General Medicine Isoquinolines Endocrinology Neurology chemistry Catecholamine biology.protein medicine.drug |
| Zdroj: | Alcohol. 3:215-220 |
| ISSN: | 0741-8329 |
| DOI: | 10.1016/0741-8329(86)90047-9 |
| Popis: | The effect of acetaldehyde on urinary salsolinol (6, 7-dihydroxy-l-methyl-1,2,3,4-tetrahydroisoquinoline) after ethanol intake was investigated. Healthy Japanese male volunteers were divided into two groups, i.e., a normal aldehyde dehydrogenase (ALDH) group of 13 subjects with a low Km isozyme of ALDH and a deficient group of 12 subjects. The subjects were given 0.4 or 0.8 g/kg of ethanol. Blood ethanol and acetaldehyde levels, urinary excretions of salsolinol, norepinephrine, epinephrine and dopamine were determined. A significant elevation of salsolinol in urine was found after intake of 0.8 g/kg of ethanol in the two groups, but the increase in the deficient group was greater than that in the normal group, while 0.4 g/kg of ethanol did not affect the excretion of salsolinol in either group. Blood acetaldehyde was highly correlated with urinary salsolinol (r = 0.88, p less than 0.001) and the correlation coefficient was greater than that between blood ethanol and salsolinol. |
| Databáze: | OpenAIRE |
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