Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease
| Autor: | Guy A. Cabral, Denise A. Dove Pettit |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Substance-Related Disorders
Immunology Biology Pharmacology medicine.disease_cause Cannabis sativa Marijuana use Immunity mental disorders Delta-9-tetrahydrocannabinol medicine Animals Humans Immunology and Allergy Host resistance Cannabinoids organic chemicals Bacterial Infections In vitro Herpes simplex virus Neurology Virus Diseases Infectious disease (medical specialty) Immune System Neurology (clinical) |
| Zdroj: | Journal of Neuroimmunology. 83:116-123 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/s0165-5728(97)00227-0 |
| Popis: | Marijuana, Cannabis sativa, elicits a variety of effects in experimental animals and humans. Delta-9-tetrahydrocannabinol (THC) is the major psychoactive component in marijuana. This substance has been shown, also, to be immunosuppressive and to decrease host resistance to bacterial, protozoan, and viral infections. Macrophages, T lymphocytes, and natural killer cells appear to be major targets of the immunosuppressive effects of THC. Definitive data which directly link marijuana use to increased susceptibility to infection in humans currently is unavailable. However, cumulative reports indicating that THC alters resistance to infection in vitro and in a variety of experimental animals support the hypothesis that a similar effect occurs in humans. |
| Databáze: | OpenAIRE |
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