Aging, physical conditioning, and exercise-induced changes in hemostatic factors and reaction products
| Autor: | I. A. Huisveld, W. L. Mosterd, J. E. H. Hospers, P. J. M. Van Den Burg, Bonno N. Bouma |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Senescence Aging medicine.medical_specialty Physiology medicine.medical_treatment Physical Exertion Fibrin Von Willebrand factor hemic and lymphatic diseases Physiology (medical) Internal medicine Fibrinolysis medicine Humans Hemostasis Blood Volume Anthropometry medicine.diagnostic_test biology Chemistry Middle Aged Endocrinology Coagulation Physical Fitness Immunology biology.protein Plasminogen activator circulatory and respiratory physiology Partial thromboplastin time |
| Zdroj: | Journal of Applied Physiology. 88:1558-1564 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | The influence of age on training-induced changes in resting and stimulated hemostatic potential was studied in three age categories (Cat I–III; 20–30 yr, 35–45 yr, and 50–60 yr, respectively) of sedentary men before and after 12 wk of training. Coagulation, fibrinolytic activity, and activation markers (reflecting fibrin formation and degradation) were determined. Physical conditioning resulted in a more pronounced increase in von Willebrand factor (vWF) and factor VIII clotting activity (FVIII:c) in Cat I and II and a more pronounced shortening of the activated partial thromboplastin time in all categories at maximal exertion and during recovery. Enhanced increases in tissue-type plasminogen activator (t-PA) antigen and activity and single-chain (sc) urokinase-type plasminogen activator (u-PA) at maximal exercise and 5 min of recovery were observed in all age groups after training. The effects on FVIII:c, vWF, and scu-PA were most pronounced in the youngest age group (Cat I). Increases in the marker of thrombin generation were highest in Cat III; no effect was seen on thrombin-antithrombin complex, plasmin-antiplasmin complex, and D-dimer in any of the age groups. We concluded that training enhances both coagulation and fibrinolytic potential during strenuous exercise. The effect on FVIII/vWF and t-PA/u-PA is most pronounced in younger individuals, whereas thrombin formation is most pronounced in older individuals. |
| Databáze: | OpenAIRE |
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