Sucralfate interactions with gastric mucus
Autor: | Lindy L. Thomsen, Mark A. Vanderwee, C. Tasman-Jones, Gail Morrison |
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Rok vydání: | 1989 |
Předmět: |
Male
medicine.medical_specialty Sucralfate medicine.medical_treatment Potassium Sodium chemistry.chemical_element Gastroenterology Antibodies Internal medicine medicine Gastric mucosa Animals Freeze Fracturing Saline business.industry Stomach Rats Inbred Strains General Medicine Mucus Molecular biology Epithelium Rats medicine.anatomical_structure chemistry Gastric Mucosa Microscopy Electron Scanning business Electron Probe Microanalysis medicine.drug |
Zdroj: | The American Journal of Medicine. 86:5-9 |
ISSN: | 0002-9343 |
DOI: | 10.1016/0002-9343(89)90149-6 |
Popis: | Sucralfate protects the stomach against a number of experimental damaging agents and is efficacious in the treatment of peptic ulcer disease. It binds with acidity to the base of an ulcer to form a protective barrier. Sucralfate also enhances prostaglandin synthesis and release in the mucosa. In this study, the rat stomach was examined to determine sucralfate's interaction with gastric mucus. Mucus in the rat stomach forms a distinct and continuous blanket. In snap-frozen samples, pretreatment with phosphate-buffered saline as a control shows a layer of mucus of homogeneous structure thinner than the homogeneous layer after pretreatment with antibodies developed against rat gastric mucus. Pretreatment with the surface protective agent sucralfate shows some increase in the thickness of mucus with a thin dense sublayer adjacent to the epithelium and a less dense-appearing outer zone of variable thickness. Analysis of x-rays generated by the electron beam on windows of mucus and epithelium showed the expected gradients of sodium, potassium, chloride, and sulfur. The percentage of aluminum and sulfur in the mucus was higher in sucralfate-treated samples than in controls. Interaction between sucralfate and gastric mucus needs further investigation. |
Databáze: | OpenAIRE |
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