Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders
| Autor: | Ruth K. Weir, Katherine M. Ku, Jill L. Silverman, Robert F. Berman, Melissa D. Bauman |
|---|---|
| Přispěvatelé: | Pellis, Sergio |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Research Facilities Autism Spectrum Disorder Autism Social Sciences Social identity approach Rats Sprague-Dawley Mice 0302 clinical medicine Psychology Young adult Mammals Pediatric Multidisciplinary Animal Behavior Animal Models Sensory Gating Laboratory rat medicine.anatomical_structure Phenotype Mental Health Autism spectrum disorder Vertebrates Anxiety Medicine Female medicine.symptom Research Laboratories Research Article General Science & Technology Science Intellectual and Developmental Disabilities (IDD) Biology Research and Analysis Methods Rodents Basic Behavioral and Social Science 03 medical and health sciences Model Organisms Species Specificity Behavioral and Social Science medicine Animals Learning Rats Long-Evans Social Behavior Behavior Sensory gating Animal Organisms Neurosciences Biology and Life Sciences Long-Evans Social Play Collective Animal Behavior medicine.disease Rats Brain Disorders Young Adults Disease Models Animal 030104 developmental biology Age Groups Amniotes People and Places Developmental Psychology Disease Models Recreation Population Groupings Collective animal behavior Sprague-Dawley Stereotyped Behavior Zoology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | PloS one, vol 11, iss 6 PLoS ONE, Vol 11, Iss 6, p e0158150 (2016) PLoS ONE |
| Popis: | The laboratory rat is emerging as an attractive preclinical animal model of autism spectrum disorder (ASD), allowing investigators to explore genetic, environmental and pharmacological manipulations in a species exhibiting complex, reciprocal social behavior. The present study was carried out to compare two commonly used strains of laboratory rats, Sprague-Dawley (SD) and Long-Evans (LE), between the ages of postnatal day (PND) 26-56 using high-throughput behavioral phenotyping tools commonly used in mouse models of ASD that we have adapted for use in rats. We detected few differences between young SD and LE strains on standard assays of exploration, sensorimotor gating, anxiety, repetitive behaviors, and learning. Both SD and LE strains also demonstrated sociability in the 3-chamber social approach test as indexed by spending more time in the social chamber with a constrained age/strain/sex matched novel partner than in an identical chamber without a partner. Pronounced differences between the two strains were, however, detected when the rats were allowed to freely interact with a novel partner in the social dyad paradigm. The SD rats in this particular testing paradigm engaged in play more frequently and for longer durations than the LE rats at both juvenile and young adult developmental time points. Results from this study that are particularly relevant for developing preclinical ASD models in rats are threefold: (i) commonly utilized strains exhibit unique patterns of social interactions, including strain-specific play behaviors, (ii) the testing environment may profoundly influence the expression of strain-specific social behavior and (iii) simple, automated measures of sociability may not capture the complexities of rat social interactions. |
| Databáze: | OpenAIRE |
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