Genotypic and geographical distribution of porcine reproductive and respiratory syndrome viruses in mainland China in 1996-2016
| Autor: | Guangzhi Tong, Guihong Zhang, Zhi-Jun Tian, Xiao-Bo Chang, Chao Ye, Chenggang Jiang, Jia-Cong Gao, Jun-Yao Xiong, Xuehui Cai, Jin-Chao Guo, Tong-Qing An |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Mainland China China Lineage (genetic) Genotype 040301 veterinary sciences Swine Porcine Reproductive and Respiratory Syndrome Biology Microbiology 0403 veterinary science 03 medical and health sciences Phylogenetics Genetic variation Animals Porcine respiratory and reproductive syndrome virus Phylogeny Genetic diversity General Veterinary Outbreak Genetic Variation 04 agricultural and veterinary sciences General Medicine Virology 030104 developmental biology Evolutionary biology GenBank RNA Viral |
| Zdroj: | Veterinary microbiology. 208 |
| ISSN: | 1873-2542 |
| Popis: | Porcine reproductive and respiratory syndrome (PRRS) has caused huge economic losses to Chinese swine industry and remains a major threat since it was first reported in 1996. However, investigations of molecular epidemiological and genetic diversity of PRRS viruses (PRRSVs) in China were limited to a small number of representative strains collected in several areas. Moreover, lineage classifications reported by individual researchers were quite different. In the present study, we sequenced ORF5 sequences of 217 PRRSVs from clinical samples, retrieved all the available ORF5 sequences of PRRSVs isolated in China in 1996-2016 (n=2213) from GenBank, and systematically analyzed corresponding epidemiological data. NA-type PRRSVs in China were classified into five lineages: lineage 1, lineage 3, lineage 5, lineage 8, and lineage 9. Most strains in China belonged to lineage 8 (85.6%), with dominant strains being classified as sublineage 8.3 (78.3%). Importantly, the emerging lineage 1 and lineage 3 strains spread rapidly, and their proportions among circulating PRRSVs have significantly increased in recent years. The geographical distribution of different PRRSV lineages in each province was analyzed and possible inter-province transmission routes were outlined for main lineages and sublineages. To our knowledge, this study is the most comprehensive and extensive phylogeographical analysis of PRRSVs in China since PRRS outbreak in 1996. Our dataset can serve as a canonical standard for PRRSV classification and will help to study genetic evolution of PRRSV. The results of the present study may also improve prevention of PRRS in China. |
| Databáze: | OpenAIRE |
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