Brain and cognitive functions in two groups of naïve HIV patients selected for a different plan of antiretroviral therapy: A qEEG study

Autor: Susanna Cordone, Elisabetta Teti, Lorenzo Ciullini, Valentina Correr, Claudio Del Percio, Stefano Ferracuti, Antonio Aceti, Elisa Piccinni, Giuseppe Noce, Paolo Capotosto, Francesco Di Campli, Magdalena Viscione, Cristina Limatola, Paolo Roma, Claudio Babiloni, Paolo Onorati, Alfredo Pennica, Andrea Soricelli, Laura Gianserra, Chiara Muratori, Loredana Sarmati, Massimo Andreoni
Rok vydání: 2016
Předmět:
0301 basic medicine
Cart
Adult
Male
medicine.medical_specialty
Settore MED/17 - Malattie Infettive
Alpha and delta rhythms
Antiretroviral therapy (cART)
CD4 counts
Human immunodeficiency virus (HIV)
LORETA
Resting-state electroencephalography (EEG)
Anti-Retroviral Agents
Antiretroviral Therapy
Highly Active
Brain
Cognition
Electroencephalography
Female
Follow-Up Studies
HIV Infections
Humans
Antiretroviral Therapy
Alpha (ethology)
physiology (medical)
Group A
Group B
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Highly Active
alpha and delta rhythms
antiretroviral therapy (cart)
cd4 counts
human immunodeficiency virus (hiv)
loreta
resting-state electroencephalography (eeg)
sensory systems
neurology
neurology (clinical)
medicine.diagnostic_test
virus diseases
030104 developmental biology
Immunology
Hiv patients
Psychology
Viral load
030217 neurology & neurosurgery
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 127(11)
ISSN: 1872-8952
Popis: Objective Cortical sources of electroencephalographic (EEG) rhythms were investigated in two sub-populations of naive HIV subjects, grouped based on clinical criteria to receive different combination anti-retroviral therapies (cARTs). These EEG sources were hypothesized to reflect beneficial effects of both regimes. Methods Eyes-closed resting state EEG data were collected in 19 (Group A) and 39 (Group B) naive HIV subjects at baseline (i.e. pre-treatment; T0) and after 5 months of cART (T5). Compared with the Group A, the Group B was characterized by slightly worse serological parameters and higher cardiovascular risk. At T0, mean viral load (VL) and CD4 count were 87,694 copies/ml and 435 cells/μl in the Group A and 187,370 copies/ml and 331 cells/μl in the Group B. The EEG data were also collected in 50 matched control HIV-negative subjects. Cortical EEG sources were assessed by LORETA software. Results Compared to the Control Group, the HIV Groups showed lower alpha (8–12 Hz) source activity at T0 while the Group B also exhibited higher delta source activity. The treatment partially normalized alpha and delta source activity in the Group A and B, respectively, in association with improved VL, CD4, and cognitive functions. Conclusions Different cART regimens induced diverse beneficial effects in delta or alpha source activity in the two naive HIV Groups. Significance These sources might unveil different neurophysiological effects of diverse cART on brain function in naive HIV Groups as a function of clinical status and/or therapeutic compounds.
Databáze: OpenAIRE
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