Metabolic Stress: Mitochondrial Function in Neointimal Formation
| Autor: | Emily K. Nguyen, Isabella M. Grumbach |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Chemistry Apoptosis 030204 cardiovascular system & hematology Mitochondrial Dynamics Article Muscle Smooth Vascular Cell biology Mitochondria 03 medical and health sciences 030104 developmental biology 0302 clinical medicine bcl-2 Homologous Antagonist-Killer Protein Cell Movement Stress Physiological Neointima Animals Humans Metabolic Stress Cardiology and Cardiovascular Medicine Reactive Oxygen Species Function (biology) Cells Cultured Cell Proliferation Signal Transduction |
| Zdroj: | Arterioscler Thromb Vasc Biol |
| Popis: | Mitochondria regulate major aspects of cell function by producing ATP, contributing to Ca 2+ signaling, influencing redox potential, and controlling levels of reactive oxygen species. In this review, we will discuss recent findings that illustrate how mitochondrial respiration, Ca 2+ handling, and production of reactive oxygen species affect vascular smooth muscle cell function during neointima formation. We will review mitochondrial fission/fusion as fundamental mechanisms for smooth muscle proliferation, migration, and metabolism and examine the role of mitochondrial mobility in cell migration. In addition, we will summarize novel aspects by which mitochondria regulate apoptosis. |
| Databáze: | OpenAIRE |
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