Application of the genetic risk model for the analysis of predisposition to nonlacunar ischemic stroke
| Autor: | K O Mironov, E A Dunaeva, Alexander E. Platonov, Sergey N. Illarioshkin, I. A. Olkhovskiy, German A. Shipulin, Alexander Sotnikov, Elina Akselrod, M.A. Stolyar, Marina Yuryevna Maksimova, A. A. Raskurazhev, Natalia Rakova, A. S. Gorbenko, Olga Dribnokhodova, Galina Gritsan, V. I. Korchagin, Marine M. Tanashyan, Alexander Roytman |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Genotype Single-nucleotide polymorphism Disease Polymorphism Single Nucleotide Brain Ischemia Russia 03 medical and health sciences 0302 clinical medicine Discriminative model Risk Factors Internal medicine Genetic predisposition medicine Humans Genetic Predisposition to Disease Genetic Testing Genetic risk Precision Medicine Aged Pharmacology Receiver operating characteristic business.industry General Medicine Middle Aged Stroke 030104 developmental biology ROC Curve Area Under Curve Case-Control Studies Ischemic stroke Molecular Medicine Female Risk assessment business 030217 neurology & neurosurgery |
| Zdroj: | Personalized medicine. 16(5) |
| ISSN: | 1744-828X |
| Popis: | Aim: The purpose of our study was to analyze the predictive ability of the multiplicative model of genetic risk of nonlacunar ischemic stroke (IS) for independent samples from Russia. Patients & methods: A total of 181 patients and 360 healthy controls were included in this study. The discriminative accuracy of model was evaluated by the area under the receiver operating characteristic curve (AUC). Results: Classification model based on 15 single-nucleotide polymorphisms (SNPs), which are associated with a cardioembolic subtype of IS, had an AUC of 0.62 in patients with corresponding subtypes and an AUC of 0.58 for all patients. Conclusion: Risk calculation approach based on IS-associated SNPs had satisfactory performance in predicting the predisposition to the disease. |
| Databáze: | OpenAIRE |
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