Vasopressin and oxytocin regulation of cyclic AMP accumulation in rat hypothalamo-neurohypophysial explants in vitro
| Autor: | Kathleen M. Michels, Rick B. Meeker, James N. Hayward |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System endocrine system Pituitary gland medicine.medical_specialty Vasopressin Vasopressins Neuropeptide Biology Peptide hormone Oxytocin Supraoptic nucleus chemistry.chemical_compound Organ Culture Techniques Internal medicine Cyclic AMP medicine Animals Forskolin Dose-Response Relationship Drug Adenine General Neuroscience Colforsin Biological Transport Rats Inbred Strains Acetylcholine Rats Kinetics medicine.anatomical_structure Endocrinology chemistry Hypothalamus hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Neuroscience Letters. 114:225-230 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(90)90076-l |
| Popis: | Addition of vasopressin to hypothalamo-neurohypophysial explants in vitro increased cyclic AMP accumulation whereas exogenous oxytocin decreased cyclic AMP. An opposite response pattern was observed in the neural lobe of the pituitary where vasopressin decreased and oxytocin increased cyclic AMP accumulation. Forskolin elicited a 3-fold greater increase in cyclic AMP in the neural lobe than in the supraoptic nucleus and enhanced the sensitivity of the tissues to both vasopressin and oxytocin. The ability of both vasopressin and oxytocin to modulate local cyclic AMP metabolism suggests the possibility of internal feedback within the hypothalamo-neurohypophysial system. |
| Databáze: | OpenAIRE |
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