Neurobiological Substrates of Tourette's Disorder
| Autor: | Michelle Hampson, Michael H. Bloch, Megan E. Smith, Daouia Larabi, James F. Leckman |
|---|---|
| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
TRANSCRANIAL MAGNETIC STIMULATION
Dopamine medicine.medical_treatment BASAL GANGLIA OUTPUT DOPAMINE TRANSPORTER BINDING PsycINFO Tourette syndrome TIC DISORDERS Norepinephrine DOUBLE-BLIND Functional neuroimaging GABAERGIC INTERNEURONS medicine Animals Humans Attention deficit hyperactivity disorder Pharmacology (medical) Original Articles and Reviews Neurotransmitter Agents Noradrenergic neurotransmission ATTENTION-DEFICIT/HYPERACTIVITY DISORDER Dopaminergic OBSESSIVE-COMPULSIVE DISORDER RANDOMIZED CONTROLLED-TRIAL medicine.disease FUNCTIONAL NEUROANATOMY Corpus Striatum Transcranial magnetic stimulation Psychiatry and Mental health Search terms Pediatrics Perinatology and Child Health Psychology Neuroscience Tourette Syndrome |
| Zdroj: | Journal of Child and Adolescent Psychopharmacology, 20(4), 237-247. MARY ANN LIEBERT, INC |
| ISSN: | 1044-5463 |
| Popis: | Objective: This article reviews the available scientific literature concerning the neurobiological substrates of Tourette's disorder (TD).Methods: The electronic databases of PubMed, ScienceDirect, and PsycINFO were searched for relevant studies using relevant search terms.Results: Neuropathological as well as structural and functional neuroimaging studies of TD implicate not only the sensorimotor corticostriatal circuit, but also the limbic and associative circuits as well. Preliminary evidence also points to abnormalities in the frontoparietal network that is thought to maintain adaptive online control. Evidence supporting abnormalities in dopaminergic and noradrenergic neurotransmission remains strong, although the precise mechanisms remain the subject of speculation.Conclusion: Structural and functional abnormalities in multiple parallel corticostriatal circuits may underlie the behavioral manifestations of TD and related neuropsychiatric disorders over the course of development. Further longitudinal research is needed to elucidate these neurobiological substrates. |
| Databáze: | OpenAIRE |
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