Comparative Ototoxicity of Dibekacin and Netilmicin in Guinea Pigs
| Autor: | L. Parravicini, M. Marzanatti, A. Forlani, A. Arpini |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Dibekacin Guinea Pigs Labyrinth Diseases Action Potentials Stimulation Pharmacology Toxicology Nystagmus Pathologic Guinea pig Ototoxicity Kanamycin otorhinolaryngologic diseases medicine Animals Netilmicin Vestibular system business.industry Auditory Threshold medicine.disease Cochlea Compound muscle action potential Anesthesia Evoked Potentials Auditory Reflex Female Gentamicins business medicine.drug |
| Zdroj: | Acta Pharmacologica et Toxicologica. 53:230-235 |
| ISSN: | 0001-6683 |
| DOI: | 10.1111/j.1600-0773.1983.tb01130.x |
| Popis: | The cochleo- and vestibulotoxicity of dibekacin and netilmicin were compared in a guinea pig model. Both aminoglycosides were administered subcutaneously for 21 days at the dose level of 150 mg/kg/day. Control animals were injected with saline. Dibekacin-treated animals showed a significant (P less than 0.05) increase in the thresholds of the Preyer pinna reflex and the VIIIth nerve compound action potential in response to sound click stimulation. Moreover, a deterioration of the electrophysiologic auditory response and an almost complete suppression of the post-rotatory nystagmus were detected. In contrast, netilmicin did not induce any significant change in auditory and vestibular functions as compared to the control group. Our results demonstrated that netilmicin was devoid of ototoxicity in the guinea pig, while dibekacin provoked mild cochlear and severe vestibulotoxicity. |
| Databáze: | OpenAIRE |
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