Lithium Toxicity in Pregnant Swine
| Autor: | Keith W. Kelley, John J. McGlone, John A. Froseth |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
Litter Size Lithium (medication) Swine Gestational Age Lithium Biology Body weight General Biochemistry Genetics and Molecular Biology Animal science Pregnancy Internal medicine Lactation medicine Animals Birth Weight Dietary nutrients Fetal Death Lithium toxicity Body Weight medicine.disease Teratogens Endocrinology medicine.anatomical_structure Pregnancy Animal Gestation Animal Nutritional Physiological Phenomena Female Maternal body medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 158:123-127 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-158-40154 |
| Popis: | SummaryTwenty-three pregnant swine were fed either 2.3 kg of a ration containing 2818 kcal metabolizable energy kg-1 once daily or fed the same ration supplemented with 3000 mg Li2CO3 kg-1 and fed ad libitum during the final 80 days of gestation. Lithium was not fed during lactation. Lithium-fed females voluntarily consumed 2.8 kg day-1. Swine that consumed lithium lost 27 kg of body weight during gestation and weighed less (P < 0.05) than control females at 110 days of gestation. All of the control females gave birth to piglets but only 58% of the lithium-fed females completed pregnancy. Females consuming lithium gave birth to fewer (P < 0.05) live piglets, more (P < 0.01) mummies and stillbirths and lighter (P < 0.01) litters. Fewer (P < 0.01) of the liveborn piglets born to lithium-treated females survived to 21 days of age. It is suggested that lithium caused these toxic effects by interfering with absorption or metabolism of dietary nutrients. This resulted in mobilization of maternal body stores and... |
| Databáze: | OpenAIRE |
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