How glycobiology can help us treat and beat the COVID-19 pandemic
| Autor: | Eduardo O. Bravo, Pedro Parodi, Sofia de la Fuente, Ricardo D. Lardone, Anneke K. Schmider, Genaro Angeloni, Yohana Camila Garay, Fernando J. Irazoqui |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Glycan FDA-approved drugs Glycobiology Gene Expression potential therapies Biology Biochemistry Antiviral Agents Virus Glycomics 03 medical and health sciences Viral Proteins glycobiology Polysaccharides Lectins Pandemic Drug Discovery COVID-19 SARS-CoV-2 Humans Glycoside Hydrolase Inhibitors Molecular Biology FDA - approved drugs Mannan-binding lectin Glycosaminoglycans 030102 biochemistry & molecular biology Drug discovery JBC Reviews Food and Drug Administration Drug Repositioning Glycosyltransferases Covid 19 Cell Biology Antibodies Neutralizing Drug repositioning 030104 developmental biology Potential therapies Drug Design Immunology Host-Pathogen Interactions biology.protein Signal Transduction |
| Zdroj: | The Journal of Biological Chemistry The journal of biological chemistry, 296:100375 Repositorio Digital Universitario (UNC) Universidad Nacional de Córdoba instacron:UNC Journal of Biological Chemistry |
| ISSN: | 1083-351X |
| Popis: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) emerged during the last months of 2019, spreading throughout the world as a highly transmissible infectious illness designated as COVID-19. Vaccines have now appeared, but the challenges in producing sufficient material and distributing them around the world means that effective treatments to limit infection and improve recovery are still urgently needed. This review focuses on the relevance of different glycobiological molecules that could potentially serve as or inspire therapeutic tools during SARS-CoV-2 infection. As such, we highlight the glycobiology of the SARS-CoV-2 infection process, where glycans on viral proteins and on host glycosaminoglycans have critical roles in efficient infection. We also take notice of the glycan-binding proteins involved in the infective capacity of virus and in human defense. In addition, we critically evaluate the glycobiological contribution of candidate drugs for COVID19 therapy such as glycans for vaccines, anti-glycan antibodies, recombinant lectins, lectin inhibitors, glycosidase inhibitors, polysaccharides, and numerous glycosides, emphasizing some opportunities to repurpose FDA-approved drugs. For the nextgeneration drugs suggested here, biotechnological engineering of new probes to block the SARS-CoV-2 infection might be based on the essential glycobiological insight on glycosyltransferases, glycans, glycan-binding proteins, and glycosidases related to this pathology. publishedVersion Fil: Lardone Ricardo D. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica Ranwel Caputto; Argentina. Fil: Lardone Ricardo D. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. Fil: Garay Yohana C. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica Ranwel Caputto; Argentina. Fil: Garay Yohana C. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. Fil: Parodi, Pedro. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica Ranwel Caputto; Argentina. Fil: Parodi, Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. Fil: de la Fuente, Sofia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica Ranwel Caputto; Argentina. Fil: de la Fuente, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. Fil: Angeloni, Genaro. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica Ranwel Caputto; Argentina. Fil: Angeloni, Genaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. Fil: Bravo, Eduardo O. Ministerio de Salud de la Provincia de Córdoba. Nuevo Hospital San Roque; Argentina. Fil: Schmider, Anneke K. Klinik für Kinder- und Jugendpsychiatrie und Psychotherapie, Psychiatrische Klinik Lüneburg, Lüneburg; Germany. Fil: Irazoqui, Fernando J. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica Ranwel Caputto; Argentina. Fil: Irazoqui, Fernando J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. |
| Databáze: | OpenAIRE |
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