The immunological impact of preoperative chemoradiotherapy on the tumor microenvironment of pancreatic cancer

Autor: Shinichiro Takahashi, Toshihiro Suzuki, Katsuhiko Uesaka, Motohiro Kojima, Satoshi Okubo, Yasuhiro Shimizu, Hirochika Toyama, Genichiro Ishii, Naoto Gotohda, Soichiro Morinaga, Masayoshi Hioki
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Oncology
Cancer Research
Cell
immune response
0302 clinical medicine
Tumor Microenvironment
Pathology
CD20
B-Lymphocytes
Immunity
Cellular
biology
FOXP3
Forkhead Transcription Factors
General Medicine
Middle Aged
Immunohistochemistry
Neoadjuvant Therapy
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
Original Article
Carcinoma
Pancreatic Ductal
medicine.medical_specialty
Stromal cell
pancreatic ductal adenocarcinoma
macrophage
preoperative chemoradiation
03 medical and health sciences
Immune system
Pancreatic cancer
Internal medicine
Preoperative Care
medicine
Humans
Lymphocyte Count
Aged
fluorescent immunohistochemistry
Tumor microenvironment
business.industry
Macrophages
Chemoradiotherapy
Adjuvant
Original Articles
Antigens
CD20
medicine.disease
CD4 Lymphocyte Count
Pancreatic Neoplasms
030104 developmental biology
Multivariate Analysis
Cancer cell
biology.protein
Neoplasm Recurrence
Local
business
Zdroj: Cancer Science
ISSN: 1349-7006
1347-9032
Popis: Several therapeutic regimens, including neoadjuvant chemoradiation therapy (NACRT), have been reported to serve as anticancer immune effectors. However, there remain insufficient data regarding the immune response after NACRT in pancreatic ductal adenocarcinoma (PDAC) patients. Data from 40 PDAC patients that underwent surgical resection after NACRT (NACRT group) and 30 PDAC patients that underwent upfront surgery (US group) were analyzed to examine alterations in immune cell counts/distribution using a multiplexed fluorescent immunohistochemistry system. All immune cells were more abundant in the cancer stroma than in the cancer cell nest regardless of preoperative therapy. Although the stromal counts of CD4+ T cells, CD20+ B cells, and Foxp3+ T cells in the NACRT group were drastically decreased in comparison with those of the US group, counts of these cell types in the cancer cell nest were not significantly different between the two groups. In contrast, CD204+ macrophage counts in the cancer stroma were similar between the NACRT and US groups, while those in the cancer cell nests were significantly reduced in the NACRT group. Following multivariate analysis, only a high CD204+ macrophage count in the cancer cell nest remained an independent predictor of shorter relapse‐free survival (odds ratio = 2.37; P = .033). NACRT for PDAC decreased overall immune cell counts, but these changes were heterogeneous within the cancer cell nests and cancer stroma. The CD204+ macrophage count in the cancer cell nest is an independent predictor of early disease recurrence in PDAC patients after NACRT.
This study sought to investigate any potential alterations in the distribution and clinical impact of immune cells in patients with pancreatic ductal adenocarcinoma (PDAC) treated with neoadjuvant chemoradiation therapy (NACRT). The present analysis revealed that NACRT for PDAC decreased overall immune cell counts, but these changes were heterogeneous within the cancer cell nests and cancer stroma. The CD204+ macrophage count in the cancer cell nest is an independent predictor of early disease recurrence in PDAC patients after NACRT.
Databáze: OpenAIRE
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