Workers exposed to low levels of benzene present in urban air: Assessment of peripheral blood count variations

Autor: Vincenzo Cupelli, Federica De Marco, Serafino Ricci, Maria Valeria Rosati, Nicola Mucci, Giulio Arcangeli, Vittorio Antuono, Francesco Tomei, Teodorico Casale, C Sacco, B Loreti, Alessandro Pacchiarotti, Gianfranco Tomei
Rok vydání: 2016
Předmět:
Male
lymphocytes
Health
Toxicology and Mutagenesis
Physiology
010501 environmental sciences
01 natural sciences
Blood cell
Correlation
0302 clinical medicine
airborne benzene
neutrophils
blood benzene
Air Pollutants
education.field_of_study
Chemistry
Smoking
Confounding
General Medicine
Middle Aged
Pollution
Police
medicine.anatomical_structure
030220 oncology & carcinogenesis
symbols
Female
urban pollution
Environmental Monitoring
Adult
Environmental Engineering
white blood cells
Population
03 medical and health sciences
symbols.namesake
Occupational Exposure
Linear regression
medicine
Humans
Environmental Chemistry
Cities
education
0105 earth and related environmental sciences
Urban Health
Public Health
Environmental and Occupational Health
Benzene
General Chemistry
Pearson product-moment correlation coefficient
Blood Cell Count
Immunology
Linear Models
Mann–Whitney U test
Blood sampling
Zdroj: Chemosphere. 152:392-398
ISSN: 0045-6535
DOI: 10.1016/j.chemosphere.2016.01.096
Popis: Background Few studies in the literature have examined the effects of benzene on blood cells. Aim The aim of this study was to evaluate the possible correlation between the blood benzene levels and the blood cell counts. Materials and methods From a population of 2658 workers, we studied a group of 215 subjects. Each worker underwent blood sampling for the assessment of the blood benzene levels and the blood cell counts. The Mann–Whitney U test for two-mode variables and the Kruskal–Wallis test for more-than-two-mode variables were performed on all subjects. We estimated the Pearson correlation index between the variables in the total sample and the subgroups divided according to sex, the smoking habit, and job. After the main confounding factors were evaluated, multiple linear regression was performed on both the total sample and the subgroups. Results A significant inverse correlation was found among the blood benzene levels and the white blood cells, lymphocytes, and neutrophils in traffic policemen, motorcyclists, and other outdoor workers. We did not find any significant correlation with any other parameters of blood cell count. Discussion and conclusions Our results, which must be considered preliminary, indicate that increased blood benzene levels in outdoor workers lead to decreased counts of white blood cells, neutrophils, and lymphocytes, because of possible immune effects. These are worth investigating in the future by specific immune tests.
Databáze: OpenAIRE
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