Evaluation of neurobehavioral activities of ethanolic extract of Psidium guajava Linn leaves in mice model
| Autor: | Amit Kumar Tarafdar, Farhana Islam, Debashish Mondol, Protic Jodder, Md. Abu Saleh, Sonchita Biswas, Samiron Sana |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Anxiolytic
medicine.drug_class Male mice lcsh:RS1-441 Biology Body weight Marble burying lcsh:Pharmacy and materia medica 03 medical and health sciences 0302 clinical medicine Psidium guajava Linn medicine 030304 developmental biology 0303 health sciences Psidium Traditional medicine lcsh:RM1-950 Phytochemical screening Terpenoid lcsh:Therapeutics. Pharmacology Phytochemical Mechanism of action 030220 oncology & carcinogenesis Neuropharmacological activity Anti-depressant medicine.symptom |
| Zdroj: | Future Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-12 (2021) |
| ISSN: | 2314-7253 |
| Popis: | Background The complementary and alternative medicines have particular importance in treating various comorbid conditions including anxiety and depression which prevalence will be raised to the second highest risk of morbidity, triggering a noteworthy socioeconomic burden. Ethanolic extract of leaves of Psidium guajava Linn (EEPG) was investigated to evaluate the anxiolytic and anti-depressant activity into two different doses (200 mg/kg and 400 mg/kg of body weight) on Swiss Albino male mice utilizing experimental paradigms of anxiety and depression. The extract was also subjected to phytochemical screening. Results Phytochemicals screening showed the presence of numerous types of active constituents in extract, for example, flavonoids, alkaloids, terpenoids, and steroids. The experimental results revealed that in case of anxiolytic activity tests, a statistical significant (p Conclusions Taken together, the present research work evidences the anxiolytic and anti-depressant effects of EEPG, but further investigation needed to find out the underlying mechanism of action and to isolate and purify the specific components that are responsible for aforementioned activities. |
| Databáze: | OpenAIRE |
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