Novel strategies for rapid identification and susceptibility testing of MRSA
| Autor: | Karen C. Carroll, Masako Mizusawa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Methicillin-Resistant Staphylococcus aureus Susceptibility testing Staphylococcus aureus Penicillin binding proteins 030106 microbiology Microbial Sensitivity Tests medicine.disease_cause Microbiology 03 medical and health sciences 0302 clinical medicine Virology Medicine Animals Humans 030212 general & internal medicine Whole genome sequencing business.industry biochemical phenomena metabolism and nutrition Length of Stay Staphylococcal Infections bacterial infections and mycoses Phenotype Anti-Bacterial Agents Rapid identification Infectious Diseases Molecular Diagnostic Techniques business Hospital stay |
| Zdroj: | Expert review of anti-infective therapy. 18(8) |
| ISSN: | 1744-8336 |
| Popis: | Methicillin-resistantWe searched relevant papers in PubMed for the last 10 years. In major papers, we scanned the bibliographies to ensure that important articles were included. This review describes screening and diagnostic test methods for MRSA and their analytical performances with a focus on rapid molecular-based assays including those that are on the horizon. Future novel technologies will allow more rapid detection of phenotypic resistance. In the case of whole-genome sequencing, detection of mutations may predict resistance, transmission, and virulence.Currently there are many diagnostic options for the detection of MRSA in surveillance and clinical samples. In general, these are highly accurate and have resulted in improvements in targeted management and reduction in hospital or intensive care unit length of stay for both MSSA and MRSA. Impact on mortality has been variable. Promising novel technologies will not only accurately identify pathogens and detect their resistance markers but will allow discovery of virulence determinants that might further affect patient management. |
| Databáze: | OpenAIRE |
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