HIV-Infected or -Exposed Children Exhibit Lower Immunogenicity to Hepatitis B Vaccine in Yaoundé, Cameroon: An Appeal for Revised Policies in Tropical Settings?

Autor:	Roger Somo Moyou, Hyppolite K. Tchidjou, Veronique Penlap, Joseph Fokam, christian Taheu Ngounouh, Vittorio Colizzi, Philippe Salomon Nguwoh, Anne Esther Njom Nlend, Jean Mbede Otélé, Constant Anatole Pieme
Rok vydání:	2016
Předmět:	RNA viruses 0301 basic medicine Pediatrics Human immunodeficiency virus (HIV) Breastfeeding lcsh:Medicine Pathology and Laboratory Medicine medicine.disease_cause Geographical Locations Families 0302 clinical medicine Immunodeficiency Viruses Medicine and Health Sciences Public and Occupational Health Cameroon 030212 general & internal medicine lcsh:Science Immune Response Children Vaccines Multidisciplinary Immunogenicity virus diseases Vaccination and Immunization Vaccination Medical Microbiology Viral Pathogens Viruses Pathogens Pediatric Infections Research Article medicine.medical_specialty Hepatitis B vaccine Immunology Context (language use) Microbiology 03 medical and health sciences Retroviruses medicine Microbial Pathogens Settore MED/04 - Patologia Generale business.industry lcsh:R Lentivirus Organisms Biology and Life Sciences HIV Odds ratio 030104 developmental biology Immunization Age Groups People and Places Africa lcsh:Q Population Groupings Preventive Medicine business
Zdroj:	PLoS ONE PLoS ONE, Vol 11, Iss 9, p e0161714 (2016)
ISSN:	1932-6203
Popis:	Background Since 2005, anti-hepatitis B virus (anti-HBV) vaccine is part of the Expanded Program on Immunization (EPI) for infants born in Cameroon, with 99% anti-HBV coverage. In a context of generalized HIV epidemiology, we assessed paediatric anti-HBV vaccine response according to HIV status, feeding option and age in a tropical context. Methodology Prospective, observational and cross-sectional study conducted among 82 children (27 [IQR: 9–47] months, min-max: 6–59), after complete anti-HBV vaccination (Zilbrix Hepta: 10μg AgHBs) at the Essos Health Centre in Yaounde, Cameroon, classified as group-A: HIV unexposed (28), group-B: HIV-exposed/uninfected (29), group-C: HIV-infected (25). Quantitative anti-HBs ELISA was interpreted as “no”, “low-” or “protective-response” with
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da9585276c88671976a09f4e1f0d216 https://doi.org/10.1371/journal.pone.0161714 Zobrazit plný text záznamu