Synthesis of 4-Tetrazolyl-Substituted 3,4-Dihydroquinazoline Derivatives with Anticancer Activity via a One-Pot Sequential Ugi-Azide/Palladium-Catalyzed Azide-Isocyanide Cross-Coupling/Cyclization Reaction

Autor:	Jun Xiong, Hui-Ting He, He-Yu Yang, Zhi-Gang Zeng, Cheng-Ran Zhong, Hang Shi, Meng-Ling Ouyang, Yuan-Yuan Tao, Yong-Long Pang, Yang-Hong Zhang, Bo Hu, Zi-Xiang Fu, Xiao-Lei Miao, Hai-Li Zhu, Gang Yao
Rok vydání:	2022
Předmět:	Azides Cyanides Molecular Structure Cyclization Organic Chemistry Catalysis Palladium
Zdroj:	The Journal of Organic Chemistry. 87:9488-9496
ISSN:	1520-6904 0022-3263
Popis:	A new one-pot preparation of 4-tetrazolyl-3,4-dihydroquinazolines has been reported. The Ugi-azide reactions of 2-azidobenzaldehydes, amines, trimethylsilyl azide, and isocyanides produced azide intermediates without separation, which were treated with isocyanides to give 4-tetrazolyl-3,4-dihydroquinazoline derivatives through a sequential Palladium-catalyzed azide-isocyanide cross-coupling/cyclization reaction in moderate to good yields. The biological evaluation demonstrated that compound
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da81f93b6a4cbe002d2005f2afd044f https://doi.org/10.1021/acs.joc.2c00382 Zobrazit plný text záznamu