Placental growth factor testing for suspected pre-eclampsia: a cost-effectiveness analysis
| Autor: | Andrew Shennan, Jo Ficquet, Sonia Barnfield, Asma Khalil, Gabrielle Bambridge, Lucy C Chappell, Paul T. Seed, Rachael Hunter, Joanna Girling, Kate E. Duhig, Jenny Myers, Rachna Bahl |
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| Rok vydání: | 2019 |
| Předmět: |
Placental growth factor
Adult medicine.medical_specialty placental growth factor pre-eclampsia Cost-Benefit Analysis Population Maternal Medicine Gestational Age law.invention Preeclampsia 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Pre-Eclampsia law Pregnancy medicine Economic analysis Cluster Analysis Humans education Diagnostic Techniques Obstetrical and Gynecological health care economics and organizations Placenta Growth Factor education.field_of_study 030219 obstetrics & reproductive medicine Eclampsia business.industry Pregnancy Outcome Obstetrics and Gynecology Cost-effectiveness analysis medicine.disease pre‐eclampsia United Kingdom Pregnancy Complications Models Economic Emergency medicine Gestation Female business Biomarkers |
| Zdroj: | Duhig, K E, Seed, P T, Myers, J E, Bahl, R, Bambridge, G, Barnfield, S, Ficquet, J, Girling, J C, Khalil, A, Shennan, A H, Chappell, L C & Hunter, R M 2019, ' Placental growth factor testing for suspected pre-eclampsia : a cost-effectiveness analysis ', BJOG: An International Journal of Obstetrics and Gynaecology, vol. 126, no. 11, pp. 1390-1398 . https://doi.org/10.1111/1471-0528.15855 Bjog Duhig, K E, Seed, P T, Myers, J E, Bahl, R, Bambridge, G, Barnfield, S, Ficquet, J, Girling, J C, Khalil, A, Shennan, A H, Chappell, L C & Hunter, R M 2019, ' Placental growth factor testing for suspected pre-eclampsia: a cost-effectiveness analysis ', BJOG: an international journal of obstetrics and gynaecology, vol. 126, no. 11, pp. 1390-1398 . https://doi.org/10.1111/1471-0528.15855, https://doi.org/10.1111/1471-0528.15855 |
| ISSN: | 1471-0528 |
| Popis: | Objective To calculate the cost‐effectiveness of implementing PlGF testing alongside a clinical management algorithm in maternity services in the UK, compared with current standard care. Design Cost‐effectiveness analysis. Setting Eleven maternity units participating in the PARROT stepped‐wedge cluster‐randomised controlled trial. Population Women presenting with suspected pre‐eclampsia between 20+0 and 36+6 weeks’ gestation. Methods Monte Carlo simulation utilising resource use data and maternal adverse outcomes. Main outcome measures Cost per maternal adverse outcome prevented. Results Clinical care with PlGF testing costs less than current standard practice and resulted in fewer maternal adverse outcomes. There is a total cost‐saving of UK£149 per patient tested, when including the cost of the test. This represents a potential cost‐saving of UK£2,891,196 each year across the NHS in England. Conclusions Clinical care with PlGF testing is associated with the potential for cost‐savings per participant tested when compared with current practice via a reduction in outpatient attendances, and improves maternal outcomes. This economic analysis supports a role for implementation of PlGF testing in antenatal services for the assessment of women with suspected pre‐eclampsia. Tweetable abstract Placental growth factor testing for suspected pre‐eclampsia is cost‐saving and improves maternal outcomes. Tweetable abstract Placental growth factor testing for suspected pre‐eclampsia is cost‐saving and improves maternal outcomes. |
| Databáze: | OpenAIRE |
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