Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis

Autor:	Alejandro Prieto-Castañeda, Fernando García-Garrido, Carolina Díaz-Norambuena, Blanca Escriche-Navarro, Alba García-Fernández, Jorge Bañuelos, Esther Rebollar, Inmaculada García-Moreno, Ramón Martínez-Máñez, Santiago de la Moya, Antonia R. Agarrabeitia, María J. Ortiz
Přispěvatelé:	Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Eusko Jaurlaritza, Generalitat Valenciana, Comunidad de Madrid, European Commission
Rok vydání:	2022
Předmět:	Boron Compounds dimers Photosensitizing Agents Photochemotherapy Polymers QUIMICA INORGANICA Organic Chemistry rational design Química orgánica photosensitizers Physical and Theoretical Chemistry Biochemistry
Zdroj:	E-Prints Complutense. Archivo Institucional de la UCM instname Addi. Archivo Digital para la Docencia y la Investigación Digital.CSIC. Repositorio Institucional del CSIC ORGANIC LETTERS r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) Organic Letters r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
ISSN:	1523-7060
Popis:	6 pags., 4 figs. We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprecedented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY-BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis. The authors acknowledge Spanish MICINN (PID2020-11455GB-C31, -C32, and -C33 and RTI2018-100910-BC41), Spanish Instituto de Salud Carlos III (IFI19/00026), Gobierno Vasco (IT1639-22), and Generalitat Valenciana (PROMETEO 2018/024) for financial support. A.P.-C. thanks Comunidad de Madrid for a research contract. C.D.-N. thanks MICINN for a FPI contract. B.E.-N. thanks the IFI19/00026 project, which is co-funded by the European Union, for a research contract.
Databáze:	OpenAIRE
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