Artemisinin-Resistant Plasmodium falciparum with High Survival Rates, Uganda, 2014–2016

Autor: Alex Olia, Miki Sakurai-Yatsushiro, Toshihiro Horii, Mary A. Auma, Mie Ikeda, Megumi Kaneko, Denis A Anywar, Makoto Hirai, Joseph Okello-Onen, Takafumi Tsuboi, Masatoshi Kataoka, Betty Balikagala, Eisaku Kimura, Shouki Yatsushiro, Osbert T. Katuro, Masato Yamauchi, Makoto Sekihara, Muneaki Hashimoto, Paul S. Obwoya, Toshihiro Mita, Shin-Ichiro Tachibana, Nirianne Marie Q. Palacpac, Nobuyuki Takahashi, Emmanuel I. Odongo-Aginya, Jun Ohashi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Epidemiology
lcsh:Medicine
Drug resistance
Parasite hosting
Uganda
Artemisinin
Malaria
Falciparum
biology
Artemisinins
Survival Rate
Infectious Diseases
Phenotype
Child
Preschool
Female
medicine.drug
Microbiology (medical)
medicine.medical_specialty
Genotype
Artemisinin-Resistant P. falciparum
Uganda
030106 microbiology
Plasmodium falciparum
malaria
parasites
History
21st Century
Artemisinin-Resistant Plasmodium falciparum with High Survival Rates
Uganda
2014–2016
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Drug treatment
Antimalarials
Antibiotic resistance
parasitic diseases
medicine
Humans
lcsh:RC109-216
antimicrobial resistance
drug resistance
Whole Genome Sequencing
Public health
Research
lcsh:R
medicine.disease
biology.organism_classification
Virology
Cross-Sectional Studies
Mutation
Malaria
Zdroj: Emerging Infectious Diseases, Vol 24, Iss 4, Pp 718-726 (2018)
Emerging Infectious Diseases
ISSN: 1080-6059
1080-6040
Popis: Because ≈90% of malaria cases occur in Africa, emergence of artemisinin-resistant Plasmodium falciparum in Africa poses a serious public health threat. To assess emergence of artemisinin-resistant parasites in Uganda during 2014-2016, we used the recently developed ex vivo ring-stage survival assay, which estimates ring-stage-specific P. falciparum susceptibility to artemisinin. We conducted 4 cross-sectional surveys to assess artemisinin sensitivity in Gulu, Uganda. Among 194 isolates, survival rates (ratio of viable drug-exposed parasites to drug-nonexposed controls) were high (>10%) for 4 isolates. Similar rates have been closely associated with delayed parasite clearance after drug treatment and are considered to be a proxy for the artemisinin-resistant phenotype. Of these, the PfKelch13 mutation was observed in only 1 isolate, A675V. Population genetics analysis suggested that these possibly artemisinin-resistant isolates originated in Africa. Large-scale surveillance of possibly artemisinin-resistant parasites in Africa would provide useful information about treatment outcomes and help regional malaria control.
Databáze: OpenAIRE
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