Demonstration of Spleen Colonies on Grafted Spleens in the Radiation Chimera
| Autor: | J. G. Sharp, D. A. Crouse, Alton N. Boynton |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Isograft Splenectomy Bone Marrow Cells Spleen Endogeny Biology Radiation Dosage Transplantation Autologous Mice Cell injection Bone Marrow Culture Techniques medicine Animals Transplantation Homologous Bone Marrow Transplantation Colony-forming unit Hematology Molecular biology Clone Cells Radiation Effects medicine.anatomical_structure Radiation Chimera Photon beams Cell Division |
| Zdroj: | Scandinavian Journal of Haematology. 11:92-96 |
| ISSN: | 0036-553X |
| DOI: | 10.1111/j.1600-0609.1973.tb00100.x |
| Popis: | We have demonstrated the post-irradiation development of countable endogenous spleen colonies in spleens transplanted intraperitoneally 6 weeks prior to X-irradiation of the host. We have further demonstrated countable exogenous spleen colonies on spleen grafts transplanted prior to the irradiation of the host and the injection of bone-marrow cells. Although autografted spleens in irradiated recipients did not attain their presplenectomy mass, the number of colony forming units (CFU)/105 injected cells assayed after irradiation and bone-marrow cell injection was about the same as in sham-splenectomized mice. Isografted spleens in sham-splenectomized mice were much smaller than the host or autografted spleens and the number of CFU/105 injected cells assayed per isograft was only 25–33 % of that observed in host mice. |
| Databáze: | OpenAIRE |
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