Clinicopathological and Prognostic Characteristics of Triple-Negative Breast Cancer (TNBC) in Chinese Patients: A Retrospective Study
| Autor: | Xiao Bei Zhang, Chunyan Li, Pei Wang, Guo Fang Hou, Sheng Zhang, Jin Zhang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Oncology China Cancer Research medicine.medical_specialty Adolescent Receptor ErbB-2 Epidemiology Triple Negative Breast Neoplasms Immunoenzyme Techniques Young Adult Breast cancer Internal medicine medicine Carcinoma Humans Neoplasm Invasiveness Neoplasm Metastasis Family history Survival rate Lymph node Triple-negative breast cancer Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Carcinoma Ductal Breast Public Health Environmental and Occupational Health Cancer Retrospective cohort study Middle Aged Prognosis medicine.disease Survival Rate Carcinoma Lobular medicine.anatomical_structure Receptors Estrogen Lymphatic Metastasis Female Neoplasm Grading Neoplasm Recurrence Local Receptors Progesterone business Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 14:3779-3784 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2013.14.6.3779 |
| Popis: | Aims: To determine the clinical, pathological and prognostic features associated with triple-negative breast cancer (TNBC). Methods: Clinical and histologic data of 21,749 breast cancer patients who were treated at Tianjin Medical University Cancer Institute and Hospital between July 2002 and December 2011 were collected. Patients were divided into two groups: those with TNBC and those with other types of breast cancer. Patients and tumor characteristics were compared between the two groups using the Chi-square test. The prognostic results of 9,823 patients in the study population were also analyzed to determine long-term survival rates in the two groups of breast cancer patients. Results: Among the breast cancer patients treated in our hospital between 2003 and 2011, 10.4%-13.5% of them had triple-negative breast cancers. Data analyses revealed significant differences in disease onset age, family history of breast cancer, tumor size, tumor histologic grade, lymph note positivity and metastatic status between TNBC and non-TNBC patients. There were also significant differences in 5-year, 7-year and 9-year disease-free and 7-year and 9-year overall survival probability between the groups. Conclusions:TNBC are associated with younger disease onset age, larger tumor size, higher rate of axillary lymph node positivity, and higher tumor histologic grade. TNBC is also related to family history of breast cancer, increased metastatic risk and poor prognosis. |
| Databáze: | OpenAIRE |
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