Characterization of classical major histocompatibility complex (MHC) class II genes in northern pig-tailed macaques ( Macaca leonina )
| Autor: | Xiao-Dong Lian, Xi-He Zhang, Zheng-Xi Dai, Yong-Tang Zheng |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Genes MHC Class II Immunogenetics Major histocompatibility complex Microbiology Macaque MHC Class II Gene 03 medical and health sciences 0302 clinical medicine biology.animal Genetics Animals Amino Acid Sequence Selection Genetic Molecular Biology Alleles Phylogeny Ecology Evolution Behavior and Systematics MHC class II Polymorphism Genetic biology Phylogenetic tree MHC Class I Gene Sequence Analysis DNA biology.organism_classification Macaca leonina 030104 developmental biology Infectious Diseases biology.protein Macaca 030215 immunology |
| Zdroj: | Infection, Genetics and Evolution. 56:26-35 |
| ISSN: | 1567-1348 |
| DOI: | 10.1016/j.meegid.2017.10.015 |
| Popis: | The northern pig-tailed macaque (Macaca leonina) has been identified as an independent species from the pig-tailed macaque group. The species is a promising animal model for HIV/AIDS pathogenesis and vaccine studies due to susceptibility to HIV-1. However, the major histocompatibility complex (MHC) genetics in northern pig-tailed macaques remains poorly understood. We have previously studied the MHC class I genes in northern pig-tailed macaques and identified 39 novel alleles. Here, we describe the MHC class II alleles in all six classical loci (DPA, DPB, DQA, DQB, DRA, and DRB) from northern pig-tailed macaques using a sequence-based typing method for the first time. A total of 60 MHC-II alleles were identified of which 27 were shared by other macaque species. Additionally, northern pig-tailed macaques expressed a single DRA and multiple DRB genes similar to the expression in humans and other macaque species. Polymorphism and positive selection were detected, and phylogenetic analysis suggested the presence of a common ancestor in human and northern pig-tailed macaque MHC class II allelic lineages at the DQA, DQB, and DRB loci. The characterization of full-length MHC class II alleles in this study significantly improves understanding of the immunogenetics of northern pig-tailed macaques and provides the groundwork for future animal model studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect