Ventilation-perfusion relationships in pulmonary arterial hypertension: effect of intravenous and inhaled prostacyclin treatment
| Autor: | Ivar Randmaa, Jacek Nowak, Tomas Bratel, Lars-Åke Brodin, Lars Lagerstrand |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Cardiac Catheterization Physiology Systole Hypertension Pulmonary Vital Capacity Hemodynamics Administration Oral Blood Pressure Ventilation/perfusion ratio Forced Expiratory Volume medicine Humans Aged Multiple inert gas elimination technique business.industry General Neuroscience respiratory system Middle Aged medicine.disease Pulmonary hypertension Epoprostenol respiratory tract diseases Blood pressure medicine.anatomical_structure Inhalation Echocardiography Anesthesia Injections Intravenous Vascular resistance Exercise Test Quality of Life Female Vascular Resistance business Platelet Aggregation Inhibitors Iloprost medicine.drug |
| Zdroj: | Respiratory physiologyneurobiology. 158(1) |
| ISSN: | 1569-9048 |
| Popis: | In seven patients with idiopathic or secondary pulmonary arterial hypertension (PAH), ventilation–perfusion ( V ˙ A / Q ˙ ) relationships were measured during a right heart catheterization using the multiple inert-gas elimination technique before and during intravenous infusion with epoprostenol (EPO), and following 5 months of 20 μg inhaled iloprost taken three times daily (ILO). Pre-treatment pulmonary vascular resistance (PVR) was 9.3 ± 5.0 mmHg/l/min and the dispersion of perfusion and ventilation for V ˙ A / Q ˙ -ratios was increased. EPO reduced PVR by 20%, and increased cardiac output, shunt, and mixed venous oxygenation ( S v ¯ O 2 ). The arterial oxygen tension ( P a O 2 ) remained unchanged. Basal central haemodynamics did not change after 5 months of ILO. Fifteen minutes after ILO, PVR decreased by 20%, and the shunt, S v ¯ O 2 , and P a O 2 remained unaltered. Conclusions In secondary PAH with normal lung volumes, significant V ˙ A / Q ˙ mismatching occurred. The PVR was reduced to a similar degree during EPO and after ILO, but only EPO increased the shunt and S v ¯ O 2 . EPO and ILO did not significantly affect the P a O 2 . |
| Databáze: | OpenAIRE |
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