Improvement of Cardiac Function After Roux-en-Y Gastric Bypass in Morbidly Obese Patients Without Cardiac History Measured by Cardiac MRI

Autor: Roelf A Niezen, Erwin van der Harst, René A Klaassen, Vera A A van Houten, Marinus A van den Dorpel, Leontine H. Wijngaarden, Dennis de Witte, Tobias Bruning
Přispěvatelé: Radiology & Nuclear Medicine
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Cardiac function curve
Adult
Cardiac output
medicine.medical_specialty
Left ventricular ejection fraction
Roux-en-Y gastric bypass
Endocrinology
Diabetes and Metabolism
Original Contributions
Gastric Bypass
030209 endocrinology & metabolism
Pilot Projects
030204 cardiovascular system & hematology
Left ventricular hypertrophy
Ventricular Function
Left
Left ventricular mass
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Cardiac magnetic resonance imaging
Internal medicine
Weight Loss
medicine
Humans
Obesity
Body surface area
Bariatric surgery
Nutrition and Dietetics
Ejection fraction
medicine.diagnostic_test
business.industry
Stroke Volume
Stroke volume
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Obesity
Morbid
Treatment Outcome
Cardiology
cardiovascular system
Surgery
Metabolic syndrome
business
Follow-Up Studies
Zdroj: Obesity Surgery
Obesity Surgery, 30(7), 2475-2481. Springer New York
ISSN: 1708-0428
0960-8923
Popis: Purpose Metabolic syndrome in patients with morbid obesity causes a higher cardiovascular morbidity, eventually leading to left ventricular hypertrophy and decreased left ventricular ejection fraction (LVEF). Roux-en-Y gastric bypass (RYGB) is considered the gold standard modality for treatment of morbid obesity and might even lead to improved cardiac function. Our objective is to investigate whether cardiac function in patients with morbid obesity improves after RYGB. Materials and Methods In this single center pilot study, 15 patients with an uneventful cardiac history who underwent RYGB were included from May 2015 to March 2016. Cardiac function was measured by cardiac magnetic resonance imaging (CMRI), performed preoperatively and 3, 6, and 12 months postoperative. LVEF and myocardial mass and cardiac output were measured. Results A total of 13 patients without decreased LVEF preoperative completed follow-up (mean age 37, 48.0 ± 8.8). There was a significant decrease of cardiac output 12 months postoperative (8.3 ± 1.8 preoperative vs. 6.8 ± 1.8 after 12 months, P = 0.001). Average myocardial mass declined by 15.2% (P P = 0.36). There was a significant improvement of LVEF/BSA at 6 and 12 months postoperative (26.2 ± 4.1 preoperative vs. 28.4 ± 3.4 and 29.2 ± 3.6 respectively, both P = 0.002). Additionally, there was a significant improvement of stroke volume/BSA 12 months after surgery (45.8 ± 8.0 vs. 51.9 ± 10.7, P = 0.033). Conclusion RYGB in patients with morbid obesity with uneventful history of cardiac disease leads to improvement of cardiac function.
Databáze: OpenAIRE
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