A pleiotropic element in the medium-chain acyl coenzyme A dehydrogenase gene promoter mediates transcriptional regulation by multiple nuclear receptor transcription factors and defines novel receptor-DNA binding motifs

(n)4 -->
ISSN: 0270-7306
Přístupová URL adresa: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da2e2e7425146489e95a8a13acbd291
https://pubmed.ncbi.nlm.nih.gov/8007945
Rights: OPEN
Přírůstkové číslo: edsair.doi.dedup.....2da2e2e7425146489e95a8a13acbd291
Autor: T. Gulick, M. E. Carter, D. D. Moore, Daniel P. Kelly
Rok vydání: 1994
Předmět:
Chloramphenicol O-Acetyltransferase
Fatty Acid Desaturases
Transcription
Genetic

Ovalbumin
Receptors
Retinoic Acid

Molecular Sequence Data
Receptors
Cytoplasmic and Nuclear

Biology
Transfection
Methylation
Polymerase Chain Reaction
Acyl-CoA Dehydrogenase
Gene Expression Regulation
Enzymologic

Open Reading Frames
Cricetinae
Animals
Humans
Amino Acid Sequence
Cloning
Molecular

Promoter Regions
Genetic

Molecular Biology
Nuclear receptor co-repressor 1
Nuclear receptor co-repressor 2
Orphan receptor
Cell Nucleus
COUP Transcription Factor I
Retinoid X receptor alpha
Base Sequence
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Cell Biology
Retinoid X receptor gamma
Phosphoproteins
Neuron-derived orphan receptor 1
Nuclear receptor coactivator 1
DNA-Binding Proteins
Retinoid X Receptors
Biochemistry
Hepatocyte Nuclear Factor 4
embryonic structures
Nuclear receptor coactivator 2
Oligonucleotide Probes
Chickens
Transcription Factors
Research Article
Zdroj: Molecular and cellular biology. 14(7)
ISSN: 0270-7306
Popis: We previously identified a complex regulatory element in the medium-chain acyl coenzyme A dehydrogenase gene promoter that confers transcriptional regulation by the retinoid receptors RAR and RXR and the orphan nuclear receptor HNF-4. In this study we demonstrate a trans-repressing regulatory function for the orphan receptor COUP-TF at this same nuclear receptor response element (NRRE-1). The transcriptional regulatory properties and receptor binding sequences of each nuclear receptor response element within NRRE-1 are also characterized. NRRE-1 consists of four potential nuclear hormone receptor hexamer binding sites, arranged as [-3-->(n)4
Databáze: OpenAIRE