Practical Role of Racemization Rates in Deracemization Kinetics and Process Productivities
| Autor: | Gérard Coquerel, Clément Brandel, Marine Hoquante, Ryusei Oketani, Pascal Cardinael |
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| Přispěvatelé: | BRANDEL, Clément, Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Propre |
| Předmět: |
[CHIM.INOR] Chemical Sciences/Inorganic chemistry
Temperature cycling [CHIM.INOR]Chemical Sciences/Inorganic chemistry [SPI.MAT] Engineering Sciences [physics]/Materials 010402 general chemistry 01 natural sciences [SPI.MAT]Engineering Sciences [physics]/Materials [CHIM.CRIS]Chemical Sciences/Cristallography General Materials Science Solubility [CHIM.CRIS] Chemical Sciences/Cristallography Racemization ComputingMilieux_MISCELLANEOUS Atropisomer 010405 organic chemistry Chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry General Chemistry Condensed Matter Physics [CHIM.ORGA] Chemical Sciences/Organic chemistry 0104 chemical sciences Chemical engineering Scientific method Reagent Slurry Chiral symmetry breaking |
| Zdroj: | HAL Crystal Growth & Design Crystal Growth & Design, American Chemical Society, 2018, 18 (11), pp.6417-6420 |
| ISSN: | 1528-7483 1528-7505 |
| Popis: | Herein, we report the chiral symmetry breaking of 2-methoxy-1-naphthamide atropisomers through temperature cycling without the use of any racemization reagent. The racemization rate (k1) controls the deracemization process when the cooling of the slurry is slow enough to keep the system close to equilibrium. The productivity appears proportional to the racemization rate (k1) multiplied by the solubility. |
| Databáze: | OpenAIRE |
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