Phaeohyphomycosis: Cytomorphologic Evaluation in Eleven Cases
Autor: | Rajpal Singh Punia, Ashok K. Attri, Uma Handa, Nidhi Singla, Reetu Kundu, Jagdish Chander |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male Septate medicine.medical_specialty Histology Cytodiagnosis Stain Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Cytology medicine Humans Mycosis Aged Retrospective Studies Aged 80 and over Lung business.industry Phialophora General Medicine Middle Aged 030224 pathology medicine.disease Dermatology Phaeohyphomycosis medicine.anatomical_structure Giant cell 030220 oncology & carcinogenesis Female Histopathology business Follow-Up Studies |
Zdroj: | Acta Cytologica. 64:406-412 |
ISSN: | 1938-2650 0001-5547 |
Popis: | Objective: Phaeohyphomycosis caused by phaeoid fungi is a type of mycosis emerging worldwide which causes a wide variety of clinical manifestations. Study Design: A retrospective analysis of 11 cases diagnosed with fungal inflammation on cytology over a period of 6 years (2013–2018) was done along with culture/histopathologic confirmation. Results: Of the total of 11 cases, 9 cases presented with subcutaneous swellings and 1 case each with brain and lung lesions. The age range was 30–83 years (mean: 53.6); 8 patients were male and 3 were female. Cytologic smears showed fungal profiles with septate tortuous hyphae, as well as swollen and narrow, yeast-like swellings with an irregular breadth of the hyphae in all cases. The fungal profiles were visualized on a Masson-Fontana stain. The background showed inflammatory cells, giant cells, and necrosis in variable proportions. Five cases were diagnosed as phaeohyphomycosis on cytology, whereas 3 cases were misdiagnosed as aspergillus and 2 as candida. In 1 case, typing of the fungus was not done. Histopathology was available in 5 cases, and in all these a diagnosis of phaeohyphomycosis was reached. Ten of the 11 cases had confirmation on fungal culture. Conclusions: Phaeoid fungi are rarely seen in routine cytologic practice. Careful evaluation of cytologic smears and an awareness of the characteristic morphologic features of phaeohyphomycosis are helpful in arriving at a correct diagnosis. Fine needle aspiration cytology provides a rapid diagnosis, enabling prompt therapy. |
Databáze: | OpenAIRE |
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