Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry
| Autor: | Manuel, Martinez-Selles, Luis, Almenar, Maria J, Paniagua-Martin, Javier, Segovia, Juan F, Delgado, Jose M, Arizón, Ana, Ayesta, Ernesto, Lage, Vicens, Brossa, Nicolás, Manito, Félix, Pérez-Villa, Beatriz, Diaz-Molina, Gregorio, Rábago, Teresa, Blasco-Peiró, Luis, De La Fuente Galán, Domingo, Pascual-Figal, Francisco, Gonzalez-Vilchez, Miguel, Llano |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Tissue and Organ Procurement Adolescent medicine.medical_treatment Kaplan-Meier Estimate Cardiología heart transplantation Young Adult Sex Factors Internal medicine gender Medicine Humans sex Registries Trasplante de corazón Aged Retrospective Studies Sistema cardiovascular Heart transplantation Transplantation business.industry Middle Aged Transplant Recipients Surgery Survival Rate Spain Heart Transplantation Female business Body mass index mismatch |
| Zdroj: | ABACUS. Repositorio de Producción Científica Universidad Europea (UEM) TRANSPLANT INTERNATIONAL r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 0934-0874 |
| Popis: | The results of studies on the association between sex mismatch and survival after heart transplantation are conflicting. Data from the Spanish Heart Transplantation Registry. From 4625 recipients, 3707 (80%) were men. The donor was female in 943 male recipients (25%) and male in 481 female recipients (52%). Recipients of male hearts had a higher body mass index (25.9 ± 4.1 vs. 24.3 ± 3.7; P < 0.01), and male donors were younger than female donors (33.4 ± 12.7 vs. 38.2 ± 12.3; P < 0.01). No further relevant differences related to donor sex were detected. In the univariate analysis, mismatch was associated with mortality in men (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.06–1.32; P = 0.003) but not in women (HR, 0.91; 95% CI 0.74–1.12; P = 0.4). A significant interaction was detected between sex mismatch and recipient gender (P = 0.02). In the multivariate analysis, sex mismatch was associated with long-term mortality (HR, 1.14; 95% CI 1.01–1.29; P = 0.04), and there was a tendency toward significance for the interaction between sex mismatch and recipient gender (P = 0.08). In male recipients, mismatch increased mortality mainly during the first month and in patients with pulmonary gradient >13 mmHg. Sex mismatch seems to be associated with mortality after heart transplantation in men but not in women. 2.599 JCR (2014) Q2, 50/198 Surgery; Q3, 13/25 Transplantation UEM |
| Databáze: | OpenAIRE |
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