A prospective randomized study of membrane versus bubble oxygenators in children
| Autor: | David M. Bartles, Robert M. Sade, C. Boyd Loadholt, Linda J. Campbell, James P. Dearing |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Oxygenators Membrane oxygenator Renal function Clotting functions law.invention Pulmonary function testing Bubble oxygenator Random Allocation law Cardiopulmonary bypass Medicine Humans Prospective Studies Child Lung Compliance Oxygenators Membrane Neurologic Examination Psychological Tests Cardiopulmonary Bypass business.industry Infant Newborn Infant Blood Proteins Blood proteins Blood Cell Count Oxygen Anesthesia Child Preschool Creatinine Surgery Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Annals of thoracic surgery. 29(6) |
| ISSN: | 0003-4975 |
| Popis: | We studied 60 children, 2 weeks to 10 years old, prospectively by randomly assigning them to a SciMed membrane oxygenator or Harvey bubble oxygenator. Variables of cardiopulmonary bypass (CPB) were closely controlled: prime, circuit configuration, flow rate, and blood gases. Blood variables measured at eight intervals before, during, and after operation were as follows: seven plasma proteins, free hemoglobin, formed elements, and clotting functions. Preoperatively and postoperatively, we evaluated brain function (psychological testing), renal function (creatinine clearance), and pulmonary function (compliance changes and postoperative shunt function). Postoperative blood loss, fever, and length of hospitalization were also evaluated. We compared 302 variables by computer program. No difference (p greater than 0.05) between the two groups was found in any variable related to CPB or organ function (pulmonary, renal, or cerebral) or in hematological variables except free hemoglobin. After 5 and 60 minutes of CPB and the next day, it was significantly lower (p less than 0.05) in the group with a membrane oxygenator. Safety, cost, and convenience, not physiology, should be the major factors in considering membrane versus bubble oxygenators for cardiac operations in children. |
| Databáze: | OpenAIRE |
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