High-Sensitivity C-Reactive Protein: An Independent Risk Factor for Left Ventricular Hypertrophy in Patients with Lupus Nephritis
| Autor: | Qin Wang, Jiaqi Qian, Zhaohui Ni, Zanzhe Yu, Minfang Zhang, Shan Mou, Beili Shi, Liou Cao, Hong Cai, Yucheng Yan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Article Subject Health Toxicology and Mutagenesis lcsh:Biotechnology Lupus nephritis lcsh:Medicine Left ventricular hypertrophy lcsh:Chemical technology lcsh:Technology Muscle hypertrophy Cohort Studies Risk Factors Internal medicine lcsh:TP248.13-248.65 Genetics medicine Humans lcsh:TP1-1185 cardiovascular diseases Risk factor Molecular Biology biology business.industry lcsh:T lcsh:R C-reactive protein General Medicine Middle Aged medicine.disease Lupus Nephritis C-Reactive Protein Endocrinology Echocardiography Multivariate Analysis Cohort biology.protein Cardiology Regression Analysis Molecular Medicine Female Hypertrophy Left Ventricular business Research Article Biotechnology Cohort study |
| Zdroj: | Journal of Biomedicine and Biotechnology, Vol 2010 (2010) Journal of Biomedicine and Biotechnology |
| ISSN: | 1110-7251 1110-7243 |
| Popis: | Objective. To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients. Methods. 287 LN patients (age: 38.54 ± 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis. Results. The prevalence of LVH in this cohort was 21.25% ( 𝑛 = 6 1 ). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22–30.95) versus 3.93 (1.48–9.48) mg/L, 𝑃 . 0 1 ) , and correlated with left ventricular mass index (LVMI) ( 𝑟 = 0 . 3 1 4 , 𝑃 = . 0 0 1 ). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor ( 𝛽 = 0 . 3 3 8 , 𝑃 = . 0 0 2 ) for LVH in patients with LN. Conclusions. Our findings demonstrated that serum hs-CRP level is independently correlated with LVMI and suggested that measurement of hs-CRP may provide important clinical information to investigate LVH in LN patients. |
| Databáze: | OpenAIRE |
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