Achyrocline satureioides essential oil loaded in nanocapsules ameliorate the antioxidant/oxidant status in heart of rats infected with Trypanosoma evansi
| Autor: | Silvia Gonzalez Monteiro, Luciana F. Cossetin, Carine F. Souza, Matheus D. Baldissera, Daiane Flores Dalla Lana |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
030231 tropical medicine Pharmacology Biology medicine.disease_cause Microbiology Antioxidants Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Nanocapsules Trypanosomiasis Oils Volatile medicine TBARS Animals Achyrocline satureioides Rats Wistar chemistry.chemical_classification Achyrocline Reactive oxygen species Superoxide Dismutase Myocardium Glutathione peroxidase Glutathione Catalase Oxidants Free radical scavenger Treatment Outcome 030104 developmental biology Infectious Diseases chemistry Immunology biology.protein Female Oxidative stress |
| Zdroj: | Microbial Pathogenesis. 105:30-36 |
| ISSN: | 0882-4010 |
| Popis: | Oxidative stress has been considered as a pathological mechanism that contributes to initiation and progression of cardiac injury during the Trypanosoma evansi infection. In this sense, the natural compounds with antioxidant and free radical scavenger abilities, such the Achyrocline satureioides essential oil loaded in nanocapsules (AS-NC), may be considered important approach to minimize the cardiac damage. Thus, the aim of this study was to investigate whether AS-NC treatment is able to prevents or reduce the cardiac oxidative damage in infected rats with T. evansi. Heart samples from rats infected by T. evansi showed increased reactive oxygen species (ROS), thiobarbituric reactive-acid substances (TBARS) and glutathione reduced (GSH) levels, while catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities decreased compared with uninfected and untreated animals. Also, the seric biomarkers of cardiac function increased in the infected animals compared with uninfected animals. AS-NC treatment reduced ROS and TBARS levels, ameliorate cardiac CAT and SOD activities of infected rats, and reduced seric biomarkers of cardiac function. AS-NC treatment protected the heart from oxidative stress caused by T. evansi, which might be due to its antioxidant properties. AS-NC might be considered a promising therapeutic agent against oxidative stress, when associated with nanotechnology. |
| Databáze: | OpenAIRE |
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