Preponderance of sensory versus sympathetic nerve fibers and increased cellularity in the infrapatellar fat pad in anterior knee pain patients after primary arthroplasty
| Autor: | Rainer H. Straub, Silvia Capellino, Raphael Hofbauer, Birgit Lehner, Franz Xaver Koeck, Thomas E. O. Schubert |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Arthroplasty Replacement Hip Adipose tissue Osteoarthritis Osteoarthritis Hip Fat pad Nerve Fibers Humans Medicine Knee Orthopedics and Sports Medicine Neurons Afferent Arthroplasty Replacement Knee Aged Endogenous opioid Hip surgery Pain Postoperative Infrapatellar fat pad business.industry Patella Anatomy Middle Aged Osteoarthritis Knee medicine.disease Immunohistochemistry medicine.anatomical_structure Adipose Tissue Female Adrenergic Fibers business Sensory nerve |
| Zdroj: | Journal of Orthopaedic Research. 26:342-350 |
| ISSN: | 1554-527X 0736-0266 |
| DOI: | 10.1002/jor.20498 |
| Popis: | Sensory nerve fibers transmit pain perception and secrete pro-inflammatory substance P (SP). Sympathetic nerve fibers secrete anti-inflammatory norepinephrine and endogenous opioids, which inhibit pain perception in a bidirectional crosstalk with sensory fibers. In patients with anterior knee pain after primary arthroplasty of the knee (AKP), this study investigated in parallel the innervation of the infrapatellar fat pad by sensory and sympathetic nerve fibers. A total of 32 patients with osteoarthritis (OA) of the knee (n = 10), AKP after primary knee joint replacement (n = 7), and OA of the hip (n = 15) were included. Sensory nerve fibers were semiquantitatively detected by immunohistochemistry against SP, and sympathetic nerve fibers were stained with an antibody against tyrosine hydroxylase. Cellular density of the tissue was investigated by counting cell nuclei. The density of sympathetic nerve fibers in the fat tissue was similar in knee OA as compared to AKP. In the fat tissue, density of sensory substance P-positive nerve fibers was higher in AKP than in knee OA, which was not observed in the fibrosis capsule of the fat pad. The preponderance of sensory over sympathetic nerve fibers was accompanied by an increased cellular density in fat tissue in patients with AKP compared to knee OA. A positive correlation existed between cellularity and sensory nerve fiber density in fat tissue. This study revealed a preponderance of sensory over sympathetic innervation in the infrapatellar fat pad in AKP after primary arthroplasty of the knee, which possibly leads to aggravation and continuation of AKP and local inflammation. |
| Databáze: | OpenAIRE |
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