Association between leptin and its soluble receptor with cardiometabolic risk factors in a Brazilian population
| Autor: | Pedro Hernan Cabello, Emilio Antonio Francischetti, Virginia Genelhu, Antonio Felipe Sanjuliani, C. Martins |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Blood Glucose Leptin Male medicine.medical_specialty Waist medicine.medical_treatment Blood Pressure Body Mass Index Sex Factors Insulin resistance Risk Factors Internal medicine Internal Medicine Humans Insulin Medicine Obesity Triglycerides Metabolic Syndrome Leptin receptor business.industry Cholesterol HDL Cholesterol LDL Middle Aged medicine.disease Cross-Sectional Studies Endocrinology Cardiovascular Diseases Receptors Leptin Female Insulin Resistance Waist Circumference Metabolic syndrome business Body mass index Biomarkers Brazil |
| Zdroj: | European Journal of Internal Medicine. 23:e131-e135 |
| ISSN: | 0953-6205 |
| DOI: | 10.1016/j.ejim.2012.05.016 |
| Popis: | Background Most studies evaluating the conjoint effects of leptin and human soluble leptin receptor (hs-LR) on cardiometabolic risk factors have been conducted in well-characterized ethnic groups. We aimed to assess the associations of leptin and hs-LR with the cardiometabolic risk factors that reflect the components of metabolic syndrome (MetS) in a Brazilian population with varying degrees of adiposity. Methods This is a cross-sectional analysis of adult subjects (n=173, age 45±12 years, 124 women; body mass index [BMI] 35.6±9.5 kg/m2) for association of leptin and its soluble receptor with cardiometabolic risk factors (glucose, BMI, waist circumference, hip circumference, blood pressure, insulin, cholesterol and triglycerides). Plasma hs-LR was measured by ELISA; insulin and leptin were determined by RIA. Metabolic syndrome was defined by NCEP/ATP III. Results Leptin was positively associated with blood pressure, BMI, waist circumference, hip circumference, triglycerides, glucose, insulin and HOMA and inversely correlated with HDL-cholesterol. The hs-LR exhibited inverse relationship with cardiometabolic risk factors (P≤0.006), except for glucose and lipid parameters. Leptin increased, whereas hs-LR decreased, with increasing number of MetS components (P for trend |
| Databáze: | OpenAIRE |
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