Synthesis of novel 5-substituted indirubins as protein kinases inhibitors
| Autor: | Anne Beauchard, Olivier Lozach, Thierry Besson, Laurent Meijer, Mélina Blairvacq, Valérie Thiéry, Yoan Ferandin, Stéphane Frère |
|---|---|
| Přispěvatelé: | Institut national de recherches archéologiques préventives (Inrap), Mer et santé (MS), Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Molécules et cibles thérapeutiques (MCT), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Génie Protéique et Cellulaire (LGPC), Université de La Rochelle (ULR), La Rochelle Université (ULR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC) |
| Rok vydání: | 2006 |
| Předmět: |
Indoles
Swine Clinical Biochemistry Cyclin B Pharmaceutical Science [CHIM.THER]Chemical Sciences/Medicinal Chemistry 01 natural sciences Biochemistry Glycogen Synthase Kinase 3 Starfish chemistry.chemical_compound MESH: Structure-Activity Relationship Drug Discovery CDC2-CDC28 Kinases MESH: Protein Kinase Inhibitors MESH: Animals MESH: Swine ComputingMilieux_MISCELLANEOUS MESH: Glycogen Synthase Kinase 3 MESH: Indoles MESH: Starfish Molecular Structure biology [CHIM.ORGA]Chemical Sciences/Organic chemistry Kinase MESH: Molecular Weight Stereoisomerism 3. Good health MESH: Cell Survival Enzyme inhibitor Molecular Medicine MESH: Cell Line Tumor Cell Survival MESH: Molecular Structure 010402 general chemistry Structure-Activity Relationship [CHIM.ANAL]Chemical Sciences/Analytical chemistry Cyclin-dependent kinase Cell Line Tumor Animals Humans Structure–activity relationship [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Protein kinase A MESH: CDC2-CDC28 Kinases Protein Kinase Inhibitors Molecular Biology Cyclin-dependent kinase 1 MESH: Humans 010405 organic chemistry Organic Chemistry [CHIM.CATA]Chemical Sciences/Catalysis MESH: Stereoisomerism 0104 chemical sciences Molecular Weight chemistry biology.protein Indirubin |
| Zdroj: | Bioorganic and Medicinal Chemistry Bioorganic and Medicinal Chemistry, 2006, 14 (18), pp.6434-43. ⟨10.1016/j.bmc.2006.05.036⟩ Bioorganic and Medicinal Chemistry Letters Bioorganic and Medicinal Chemistry Letters, Elsevier, 2006, 14 (18), pp.6434-6443. ⟨10.1016/j.bmc.2006.05.036⟩ Bioorganic and Medicinal Chemistry Letters, 2006, 14 (18), pp.6434-6443. ⟨10.1016/j.bmc.2006.05.036⟩ Bioorganic and Medicinal Chemistry, Elsevier, 2006, 14 (18), pp.6434-43. ⟨10.1016/j.bmc.2006.05.036⟩ |
| ISSN: | 0968-0896 1464-3391 0960-894X |
| DOI: | 10.1016/j.bmc.2006.05.036 |
| Popis: | In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, we synthesized and evaluated new 5-substituted indirubins. The effects of 34 indirubin derivatives on CDK1/cyclin B, CDK5/p25, and GSK-3, as well as on SH-SY5Y human neuroblastoma cell survival, were investigated. |
| Databáze: | OpenAIRE |
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