Interferon-gamma decreases replication of primary R5 HIV-1 isolates in thymocytes
| Autor: | W. John Boscardin, Otto O. Yang, Beverly N Redsar, Deborah J. Anisman-Posner, Livia Pedroza-Martins, Christel H. Uittenbogaart, Yvonne J. Bryson |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
CD3
Immunology Endogeny HIV Infections Thymus Gland Virus Replication Virus Interferon-gamma T-Lymphocyte Subsets Immunopathology medicine Immunology and Allergy Humans Interferon gamma Child Cells Cultured biology biology.organism_classification Virology Molecular biology Thymocyte Infectious Diseases Lentivirus biology.protein HIV-1 Viral disease medicine.drug |
| Zdroj: | AIDS (London, England). 20(6) |
| ISSN: | 0269-9370 |
| Popis: | As interferon-gamma (IFN-gamma) is produced at lower levels by neonatal than adult T cells, we determined whether IFN-gamma influences HIV-1 replication in thymocytes. IFN-gamma significantly decreased replication of R5 but not X4 viruses, and reduced depletion of CD3(hi)CD27 (mature) thymocytes, the preferential targets for R5 HIV-1. Thus infection and depletion of functionally mature thymocytes that can produce endogenous IFN-gamma may mutually contribute to HIV-1 replication in the thymus and to reduced T-cell output. |
| Databáze: | OpenAIRE |
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