Vascular inflammation, atherosclerosis, and lipid metabolism and the occurrence of non-high albuminuria diabetic kidney disease: A cross-sectional study

Autor: Yi-Yang He, Yuwei Yang, Yan Liu, Jiafu Feng, Peng Xu, Xiaohong Chen
Rok vydání: 2021
Předmět:
Adult
Male
Vasculitis
medicine.medical_specialty
Lipid Metabolism Disorder
Homocysteine
Endocrinology
Diabetes and Metabolism
Disease
Risk Assessment
chemistry.chemical_compound
Risk Factors
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Albuminuria
Humans
Diabetic Nephropathies
lipoprotein-associated phospholipase A2
Dyslipidemias
On-high albuminuria diabetic kidney disease
business.industry
Lipoprotein-associated phospholipase A2
Cholesterol
HDL
dyslipidemia
Lipid metabolism
homocysteine
Middle Aged
medicine.disease
Atherosclerosis
Lipids
Endocrinology
Cross-Sectional Studies
chemistry
1-Alkyl-2-acetylglycerophosphocholine Esterase
lipids (amino acids
peptides
and proteins)
Female
Original Article
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Dyslipidemia
Biomarkers
Zdroj: Diabetes & Vascular Disease Research
ISSN: 1752-8984
Popis: Aim: Atherosclerosis involves vascular endothelial damage and lipid metabolism disorder, which is closely related to the occurrence and development of diabetic kidney disease (DKD). However, studies on non-high albuminuria DKD (NHADKD) with an albumin to creatinine ratio (ACR) Methods: Serum lipid indicators, lipoprotein-associated phospholipase A2 (Lip-PLA2) and homocysteine levels were measured in 1116 subjects to analyze their relationship with NHADKD. Results: Among all subjects, Lip-PLA2 had the closest but relatively weak correlation with ACR ( r = 0.297, p 0.05). When ACR was ⩾10mg/g, homocysteine [OR = 17.26(9.67–30.82)] and total-Chol [OR = 5.63(2.95–10.76)] were risk factors for NHADKD, and ORhomocysteine was significantly higher than ORtotal-Chol ( Z = 3.023, p Conclusions: The occurrence of NHADKD may be related to the levels of homocysteine, total-Chol, HDL-Chol, and Lip-PLA2 in blood. Among them, homocysteine may be most closely related to NHADKD.
Databáze: OpenAIRE
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