Cu(II), Ni(II) and Co(II) complexes with homoscorpionate Bis(2-Mercaptobenzimidazolyl) and Bis(2-Mercaptobenzothiazolyl)borate ligands: Synthesis and in vitro cytotoxicity studies
| Autor: | Shirin Gilanchi, Piero Mastrorilli, Zahra Faghih, Vito Gallo, Zeinab Faghih, Abdollah Neshat |
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| Rok vydání: | 2020 |
| Předmět: |
Sodium
Salt (chemistry) Infrared spectroscopy chemistry.chemical_element 010402 general chemistry Mass spectrometry 01 natural sciences Inorganic Chemistry Metal 2-Mercaptobenzimidazole Nickel Borate ligands Cis-platin Cobalt Copper Materials Chemistry Salt metathesis reaction Physical and Theoretical Chemistry Cytotoxicity chemistry.chemical_classification 010405 organic chemistry 0104 chemical sciences chemistry visual_art visual_art.visual_art_medium Breast carcinoma Nuclear chemistry |
| Zdroj: | Inorganica Chimica Acta. 512:119896 |
| ISSN: | 0020-1693 |
| DOI: | 10.1016/j.ica.2020.119896 |
| Popis: | The salt metathesis reaction of sodium precursors, Na[H2B(mb)2] (Hmb = 2-mercapto-benzimidazole) and Na[H2B(mbt)2] (Hmbt = 2-mercapto-benzothiazole) of bipodal scorpionate ligands with Cu(OAc)2, CoCl2 and NiBr2 afforded six metal complexes, 1–6. The metal complexes were characterized using a combination of HR ESI-MS spectrometry, elemental analysis and IR spectroscopy. The cytotoxicity effect of these complexes was assessed on three human cancerous cell lines: MCF-7 (breast carcinoma), A549 (lung carcinoma) and SW1116 (colon adenocarcinoma) and compared with that for cis-platin. Our results indicated that all complexes had desirable antitumor activities ( |
| Databáze: | OpenAIRE |
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