Host cellular signaling induced by influenza virus
| Autor: | Tao Hong, Li-Shu Zhang, Xinxian Dai |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
MAPK/ERK pathway
Cell signaling Receptors Retinoic Acid viruses Biology General Biochemistry Genetics and Molecular Biology Virus Phosphatidylinositol 3-Kinases Viral Proteins Environmental Science(all) Influenza Human Humans Protein kinase B Protein Kinase C General Environmental Science Innate immune system Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) Toll-Like Receptors Pattern recognition receptor Virus Internalization Orthomyxoviridae Virology Immunity Innate Cell biology Eukaryotic Initiation Factor-4E Viral replication Host-Pathogen Interactions Signal transduction General Agricultural and Biological Sciences Signal Transduction |
| Zdroj: | Science China. Life sciences. 54(1) |
| ISSN: | 1869-1889 |
| Popis: | A wide range of host cellular signal transduction pathways can be stimulated by influenza virus infection. Some of these signal transduction pathways induce the host cell’s innate immune response against influenza virus, while others are essential for efficient influenza virus replication. This review examines the cellular signaling induced by influenza virus infection in host cells, including host pattern recognition receptor (PRR)-related signaling, protein kinase C (PKC), Raf/MEK/ERK and phosphatidylinositol- 3-kinase (PI3K)/Akt signaling, and the corresponding effects on the host cell and/or virus, such as recognition of virus by the host cell, viral absorption and entry, viral ribonucleoprotein (vRNP) export, translation control of cellular and viral proteins, and virus-induced cell apoptosis. Research into influenza virus-induced cell signaling promotes a clearer understanding of influenza virus-host interactions and assists in the identification of novel antiviral targets and antiviral strategies. |
| Databáze: | OpenAIRE |
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