Association between ABO blood types and sporadic pancreatic neuroendocrine tumors in the Chinese Han population
| Autor: | Jie Zhong, Qiwen Ben, Wei-yan Yao, Fang Guo, Weiyi Wang, Yaozong Yuan, Jun Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Neuroendocrine tumors 03 medical and health sciences 0302 clinical medicine Internal medicine ABO blood group system Medicine risk factors ABO blood type Family history Lymph node Blood type pancreatic neuroendocrine tumors business.industry Cancer Odds ratio medicine.disease Surgery 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Exocrine pancreatic cancer business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Qiwen Ben 1 , Jun Liu 2 , Weiyi Wang 4 , Fang Guo 3 , Weiyan Yao 1 , Jie Zhong 1 and Yaozong Yuan 1 1 Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, China 2 Department of Integrative Medicine, Zhongshan Hospital, Fudan University, Shanghai, China 3 Department of Geriatrics, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, China 4 Department of Endoscopy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China Correspondence to: Yaozong Yuan, email: yaozongyuan28@126.com Jie Zhong, email: jimmyzj64@medmail.com.cn Keywords: pancreatic neuroendocrine tumors, ABO blood type, risk factors Received: January 06, 2017 Accepted: May 27, 2017 Published: June 21, 2017 ABSTRACT Background: Although the relationship between non-O blood types and the risk of exocrine pancreatic cancer has been demonstrated, the association between ABO blood types and sporadic pancreatic neuroendocrine tumor (PNET) has not been reported thus far. Methods: This hospital-based, case-control study included 387 patients with PNET and 542 age- and sex-matched controls. Unconditional multivariable logistic regression analysis was performed to estimate the adjusted odds ratios (AORs) and 95% confidence intervals (CIs). The relationship between ABO blood types and clinicopathologic features was also analyzed. Results: After adjusting for age, sex, smoking status, alcohol drinking, and first-degree family history of any cancer, the AORs (95% CI) of functional PNET were 0.87 (0.59–1.28) for blood type A, 0.86 (0.58–1.28) for blood type B, and 0.71 (0.39–1.26) for blood type AB compared with subjects with blood type O. A similar ABO blood-type distribution was observed among cases with non-functional PNETs compared with controls. On comparing blood type B with non-B blood type, cases with non-functional PNETs had marginally higher rates of lymph node invasion (P = 0.047), distant metastasis (P = 0.044), and advanced European Neuroendocrine Tumor Society Stage (P = 0.040). Conclusions: There is no association between the ABO blood group and the development of functional and non-functional PNETs. The ABO blood types are not associated with the clinicopathologic features in patients with functional and non-functional PNETs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|