Y-shaped RNA secondary structure of a noncoding region in the genomic RNA of tick-borne encephalitis virus affects pathogenicity

Autor:	Shoko Nishiyama, Minato Hirano, Memi Muto, Mao Kambara, Naoto Ito, Shintaro Kobayashi, Hiroaki Kariwa, Kentaro Yoshii
Rok vydání:	2022
Předmět:	Mice Virulence Virology Immunology Animals Nucleic Acid Conformation RNA Genomics Microbiology Encephalitis Tick-Borne Encephalitis Viruses Tick-Borne
Zdroj:	Microbiology and immunologyREFERENCES. 66(5)
ISSN:	1348-0421
Popis:	Tick-borne encephalitis virus (TBEV) is a zoonotic virus that causes encephalitis in humans. Various deletions have been reported in a variable region of the 3' untranslated region of the TBEV genome. This study analyzed the role of a Y-shaped secondary structure in the pathogenicity of TBEV by using reverse genetics. Deletion of the structure increased the mortality rate of virus-infected mice but did not affect the virus multiplication in cultured cells and organs. The results indicate that the secondary structure is involved in the regulation of TBEV pathogenesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8e1bba348aad0304a56c5ba046ea4d https://pubmed.ncbi.nlm.nih.gov/35194811 Zobrazit plný text záznamu Plný text