Mitochondrial DNA in inflammation and immunity
| Autor: | Riley, Joel S., Tait, Stephen W.G. |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Mitochondrial DNA
Immunology Review Biology Mitochondrion DNA Mitochondrial Biochemistry Genome 03 medical and health sciences 0302 clinical medicine Immunity Genetics medicine Humans Molecular Biology 030304 developmental biology Inflammation 0303 health sciences Innate immune system mtDNA Pattern recognition receptor TLR9 Inflammasome immunity Immunity Innate Mitochondria Cell biology cell death Receptors Pattern Recognition Autophagy & Cell Death 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | EMBO Reports |
| ISSN: | 1469-3178 1469-221X |
| DOI: | 10.15252/embr.201949799 |
| Popis: | Mitochondria are cellular organelles that orchestrate a vast range of biological processes, from energy production and metabolism to cell death and inflammation. Despite this seemingly symbiotic relationship, mitochondria harbour within them a potent agonist of innate immunity: their own genome. Release of mitochondrial DNA into the cytoplasm and out into the extracellular milieu activates a plethora of different pattern recognition receptors and innate immune responses, including cGAS‐STING, TLR9 and inflammasome formation leading to, among others, robust type I interferon responses. In this Review, we discuss how mtDNA can be released from the mitochondria, the various inflammatory pathways triggered by mtDNA release and its myriad biological consequences for health and disease. Mitochondrial DNA is increasingly recognized as a potent agonist of innate immunity. This review discusses how mitochondrial DNA can be released from mitochondria and trigger the activation of different pro‐inflammatory signaling pathways. |
| Databáze: | OpenAIRE |
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