Persistent infection with neurotropic herpes viruses and cognitive impairment
| Autor: | R.C. Gur, Rodney C.P. Go, Monica E. Calkins, Robert H. Yolken, Bernie Devlin, Vishwajit L. Nimgaonkar, Joseph Kwentus, Alberto B. Santos, Joel Wood, Neil B. Edwards, L. D. Bradford, Jan Richard, Konasale M. Prasad, Howard W. Wiener, Robert Savage, Rodney T. Perry, Lambertus Klei, Annie M. Watson, Henry A. Nasrallah, Joseph P. McEvoy, Trina B. Allen, R.E. Gur |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Employment Male Simplexvirus food.ingredient Cytomegalovirus Neuropsychological Tests medicine.disease_cause Antibodies Viral food medicine Humans Genetic Predisposition to Disease Effects of sleep deprivation on cognitive performance Applied Psychology Principal Component Analysis Models Statistical business.industry Case-control study Brain Cognition Herpes Simplex medicine.disease Virology Black or African American Psychiatry and Mental health Herpes simplex virus Phenotype Schizophrenia Case-Control Studies Immunology Chronic Disease Cytomegalovirus Infections Multivariate Analysis Educational Status Female business Cognition Disorders Encephalitis |
| Zdroj: | Psychological medicine. 43(5) |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundHerpes virus infections can cause cognitive impairment during and after acute encephalitis. Although chronic, latent/persistent infection is considered to be relatively benign, some studies have documented cognitive impairment in exposed persons that is untraceable to encephalitis. These studies were conducted among schizophrenia (SZ) patients or older community dwellers, among whom it is difficult to control for the effects of co-morbid illness and medications. To determine whether the associations can be generalized to other groups, we examined a large sample of younger control individuals, SZ patients and their non-psychotic relatives (n=1852).MethodUsing multivariate models, cognitive performance was evaluated in relation to exposures to herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and cytomegalovirus (CMV), controlling for familial and diagnostic status and sociodemographic variables, including occupation and educational status. Composite cognitive measures were derived from nine cognitive domains using principal components of heritability (PCH). Exposure was indexed by antibodies to viral antigens.ResultsPCH1, the most heritable component of cognitive performance, declines with exposure to CMV or HSV-1 regardless of case/relative/control group status (p = 1.09 × 10−5 and 0.01 respectively), with stronger association with exposure to multiple herpes viruses (β = −0.25, p = 7.28 × 10−10). There were no significant interactions between exposure and group status.ConclusionsLatent/persistent herpes virus infections can be associated with cognitive impairments regardless of other health status. |
| Databáze: | OpenAIRE |
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