The maternal age effect: a hypothesis based on oxidative phosphorylation
| Autor: | Martin Wilding, Brian Dale, Loredana Di Matteo |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Free Radicals Ovary Oxidative phosphorylation Mitochondrion Biology Oxidative Phosphorylation Human reproduction Pregnancy Internal medicine Respiration medicine Humans Reproduction Cell Biology Oocyte medicine.disease Mitochondria medicine.anatomical_structure Endocrinology Ageing Oocytes Female Maternal Age Developmental Biology |
| Zdroj: | Zygote. 13:317-323 |
| ISSN: | 1469-8730 0967-1994 |
| DOI: | 10.1017/s0967199405003382 |
| Popis: | The ‘maternal age effect’ in human reproduction, characterized by a negative relationship between maternal age and reproductive efficiency, remains a poorly understood phenomenon. Current data suggest that oocyte physiology determines this relationship. In this review, we present a hypothesis of a mitochondrial role in the physiology of ageing in human oocytes. We suggest that the efficiency of oxidative phosphorylation in the ageing human oocyte is degraded by free radical attack on the primordial oocytes residing in the ovary. Although deficiencies in oxidative phosphorylation can be accounted for in the short term by anaerobic respiration, we suggest that, in the long term, the level of oxidative phosphorylation strongly influences oocyte quality. |
| Databáze: | OpenAIRE |
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